{"id":"d4b8ddce-b1d9-5dbb-a6e6-64e9895481c2","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-singlet-quenching","predicate":"physically_quenches","statement":"Lycopene had a reported singlet-oxygen quenching constant of 31 billion per molar per second in the assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"844657ce-42a4-51b6-a52f-4273b549d683","mechanism_event_label":"It can remove excitation energy from this reactive oxygen species.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"844657ce-42a4-51b6-a52f-4273b549d683","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-singlet-quenching-event","event_type":"biochemical_relationship","label":"It can remove excitation energy from this reactive oxygen species.","description":"Lycopene had a reported singlet-oxygen quenching constant of 31 billion per molar per second in the assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"73c24cd4-9ae8-5897-8359-fa4d9e8edecb","slug":"beta-carotene","display_name":"All-trans-beta-carotene","entity_type_key":"small_molecule"},"role":"comparison_carotenoid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"comparison_antioxidant","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/2802626.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"91ad9c300da17ee4e4c78a9ba980a7a4f05eef2328a64b5a9f75d4023abdc521\", \"start_char\": 0, \"end_char\": 1046, \"text_sha256\": \"91ad9c300da17ee4e4c78a9ba980a7a4f05eef2328a64b5a9f75d4023abdc521\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cell-free singlet-oxygen quenching comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lycopene, beta-carotene, alpha-tocopherol and albumin-bound bilirubin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rate constants are solvent/assay-dependent, not a clinical ranking of antioxidant supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Chemical assay and plasma-concentration comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"It can remove excitation energy from this reactive oxygen species.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p2802626] Lycopene as the most efficient biological carotenoid singlet oxygen quencher. (1989). https://pubmed.ncbi.nlm.nih.gov/2802626/ DOI: 10.1016/0003-9861(89)90467-0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Solution kinetics","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e3e8a390-40e1-5c48-987b-2ce632057ac0","evidence_kind":"source_excerpt","locator":"Lines 416-427","start_line":416,"end_line":427,"excerpt":"### lycopene-singlet-quenching\nLycopene had a reported singlet-oxygen quenching constant of 31 billion per molar per second in the assay.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: It can remove excitation energy from this reactive oxygen species.\norganism: Chemical assay and plasma-concentration comparison\ntissue_or_cell_type: Solution kinetics\nexperimental_model: Cell-free singlet-oxygen quenching comparison\nlimitations: Rate constants are solvent/assay-dependent, not a clinical ranking of antioxidant supplements.\nexposure: Lycopene, beta-carotene, alpha-tocopherol and albumin-bound bilirubin\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/2802626.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"91ad9c300da17ee4e4c78a9ba980a7a4f05eef2328a64b5a9f75d4023abdc521\", \"start_char\": 0, \"end_char\": 1046, \"text_sha256\": \"91ad9c300da17ee4e4c78a9ba980a7a4f05eef2328a64b5a9f75d4023abdc521\"}\n[lycopene-p2802626] Lycopene as the most efficient biological carotenoid singlet oxygen quencher. 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