{"id":"d48867fe-3f07-5bb7-99ce-aa7fc99cda14","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-ugt1a9","predicate":"is_glucuronidated_to","statement":"Human UGT1A9 was a principal contributor to 6-gingerol 5-O-glucuronide formation in the enzyme comparison.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"25886557-98dc-5de9-8dcd-e45ab9defcbd","mechanism_event_label":"Human UGT1A9 was a principal contributor to 6-gingerol 5-O-glucuronide formation in the enzyme comparison.","subject":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"03f270d7-70d5-579f-a4fb-8d3796c0c062","slug":"6-gingerol-5-o-glucuronide","display_name":"6-Gingerol 5-O-glucuronide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"25886557-98dc-5de9-8dcd-e45ab9defcbd","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-6-ugt1a9-event","event_type":"observed_relationship","label":"Human UGT1A9 was a principal contributor to 6-gingerol 5-O-glucuronide formation in the enzyme comparison.","description":"Human UGT1A9 was a principal contributor to 6-gingerol 5-O-glucuronide formation in the enzyme comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"837fdd65-c1eb-52e0-a724-42a1e9065c82","slug":"6-gingerol","display_name":"6-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"03f270d7-70d5-579f-a4fb-8d3796c0c062","slug":"6-gingerol-5-o-glucuronide","display_name":"6-Gingerol 5-O-glucuronide","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0721c8f5-4c36-500f-9df4-f34e5eeaadba","slug":"ugt1a9","display_name":"Human UDP-glucuronosyltransferase 1A9 / UGT1A9","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"fea4f3f0-7c05-59a2-9332-445b9d4f8fb0","slug":"udp-glucuronic-acid","display_name":"UDP-glucuronic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Individual 6-, 8- or 10-gingerol with UDP-glucuronic acid; exact concentration series not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human liver microsomes and expressed human UGT enzymes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"UGT2B7 favors but is not exclusive to 4-prime conjugation; UGT1A9 mainly forms 5-O conjugates. Shared UGT substrates do not prove competition in people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human liver microsomes and expressed human UGT enzymes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Human UGT1A9 was a principal contributor to 6-gingerol 5-O-glucuronide formation in the enzyme comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7. (2015). https://pubmed.ncbi.nlm.nih.gov/25496264/ DOI: 10.1111/jphp.12351","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Hepatic and recombinant enzyme preparations","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1adae02f-8b25-50e2-beef-097815fcbe60","evidence_kind":"source_excerpt","locator":"Lines 294-303","start_line":294,"end_line":303,"excerpt":"## gingerols-6-ugt1a9\nHuman UGT1A9 was a principal contributor to 6-gingerol 5-O-glucuronide formation in the enzyme comparison.\nModel/species: Human liver microsomes and expressed human UGT enzymes\nTissue: Hepatic and recombinant enzyme preparations\nExposure: Individual 6-, 8- or 10-gingerol with UDP-glucuronic acid; exact concentration series not in accessed abstract\nRoute: In vitro incubation\nDuration: Not specified in accessed abstract\nLimits: UGT2B7 favors but is not exclusive to 4-prime conjugation; UGT1A9 mainly forms 5-O conjugates. Shared UGT substrates do not prove competition in people.\nPrimary reference: Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7. (2015). https://pubmed.ncbi.nlm.nih.gov/25496264/ DOI: 10.1111/jphp.12351\nAccess: Primary PubMed abstract.","model_system":"Human liver microsomes and expressed human UGT enzymes","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text.","file_path":"","sha256":"96d1b7b04445eecd0eac1738e0c80cb6308509ecdfc3b5fc6be67ae2218cbb2b","revision_id":"de6e70ff-0e52-5c26-bd3a-54fca2085a86","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}