{"id":"d3b97605-f4dd-5340-9eca-1b8a6e86ff36","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-bmp6-overload","predicate":"loss_causes","statement":"Bmp6-null mice had reduced hepcidin expression and tissue iron overload.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"44d0f290-b8e1-5402-8794-378bcaf994ac","mechanism_event_label":"An iron-control defect can produce excess stores despite the element being essential.","subject":{"id":"58286bb2-8d24-5246-a6f2-2b67379d15db","slug":"mouse-bmp6","display_name":"Mouse bone morphogenetic protein 6 / Bmp6","entity_type_key":"protein"},"object":{"id":"618f7d71-8187-5bca-9680-9c313fe537b4","slug":"systemic-iron-overload","display_name":"Systemic tissue iron overload","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"44d0f290-b8e1-5402-8794-378bcaf994ac","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-bmp6-overload-event","event_type":"biochemical_relationship","label":"An iron-control defect can produce excess stores despite the element being essential.","description":"Bmp6-null mice had reduced hepcidin expression and tissue iron overload.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2a597498-5364-5b2c-95e2-39010dc0084c","slug":"mouse-hamp","display_name":"Mouse hepcidin / Hamp","entity_type_key":"protein"},"role":"reduced_regulator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"58286bb2-8d24-5246-a6f2-2b67379d15db","slug":"mouse-bmp6","display_name":"Mouse bone morphogenetic protein 6 / Bmp6","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"618f7d71-8187-5bca-9680-9c313fe537b4","slug":"systemic-iron-overload","display_name":"Systemic tissue iron overload","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iron-research/19252486.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b\", \"start_char\": 0, \"end_char\": 1168, \"text_sha256\": \"f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ligand binding, antibody treatment and knockout studies","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"BMP6, BMP6 antibody, soluble HJV and Bmp6 deletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mouse causal regulation; the role of other BMP ligands is not excluded.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mice and biochemical HJV/BMP systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An iron-control defect can produce excess stores despite the element being essential.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iron-p19252486] BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. (2009). https://pubmed.ncbi.nlm.nih.gov/19252486/ DOI: 10.1038/ng.335","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver, blood and tissues","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"47b4ed45-03a0-5c13-bd50-4c2a002dce29","evidence_kind":"source_excerpt","locator":"Lines 797-808","start_line":797,"end_line":808,"excerpt":"### iron-bmp6-overload\nBmp6-null mice had reduced hepcidin expression and tissue iron overload.\nCondition category: machinery_impairment\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An iron-control defect can produce excess stores despite the element being essential.\norganism: Mice and biochemical HJV/BMP systems\ntissue_or_cell_type: Liver, blood and tissues\nexperimental_model: Ligand binding, antibody treatment and knockout studies\nlimitations: Mouse causal regulation; the role of other BMP ligands is not excluded.\nexposure: BMP6, BMP6 antibody, soluble HJV and Bmp6 deletion\nevidence_span: {\"source_cache\": \"artifacts/iron-research/19252486.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b\", \"start_char\": 0, \"end_char\": 1168, \"text_sha256\": \"f51b7e3f2c0882e3da19cc1f55c13f742c4cd47ca3db21bcc40be6263af76f2b\"}\n[iron-p19252486] BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. 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