{"id":"d35f9f55-5834-5734-bcc6-e07a378406a5","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-biotin-combination-glucose","predicate":"with_biotin_reduces","statement":"Fasting glucose changed by −9.8 mg/dL with chromium picolinate plus biotin versus +0.7 mg/dL with placebo (p=0.02).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d9f7dd52-fb9e-5ada-99be-428c1fb41e43","mechanism_event_label":"The combination also improved fasting glucose in this trial.","subject":{"id":"89d5d39c-2663-5e0c-8eae-562a5b25a47d","slug":"chromium-iii-picolinate","display_name":"Chromium(III) picolinate / CrPic","entity_type_key":"chemical_species"},"object":{"id":"c14f8db4-0b3a-5323-b90b-21983e884a97","slug":"fasting-plasma-glucose","display_name":"Fasting plasma glucose","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d9f7dd52-fb9e-5ada-99be-428c1fb41e43","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-biotin-combination-glucose-event","event_type":"observed_intervention","label":"The combination also improved fasting glucose in this trial.","description":"Fasting glucose changed by −9.8 mg/dL with chromium picolinate plus biotin versus +0.7 mg/dL with placebo (p=0.02).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"37a8e96b-f95b-5ba7-a0bc-8ed3cfaf5fd8","slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"},"role":"co_intervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89d5d39c-2663-5e0c-8eae-562a5b25a47d","slug":"chromium-iii-picolinate","display_name":"Chromium(III) picolinate / CrPic","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c14f8db4-0b3a-5323-b90b-21983e884a97","slug":"fasting-plasma-glucose","display_name":"Fasting plasma glucose","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/17506119.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6e79defd1a4209f869bce07c110f0007d02eda63387c2eadc5e014a04c3fc126\", \"start_char\": 0, \"end_char\": 1739, \"text_sha256\": \"6e79defd1a4209f869bce07c110f0007d02eda63387c2eadc5e014a04c3fc126\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled combination trial; 447 enrolled","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"600 µg Cr(III) as picolinate plus 2 mg biotin/day for 90 days with stable oral diabetes medication","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"There were no chromium-only or biotin-only arms. The design cannot identify the active ingredient or prove synergy. Baseline-HbA1c subgroup effects are separately limited.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human with poorly controlled type 2 diabetes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The combination also improved fasting glucose in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p17506119] Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. (2008). https://pubmed.ncbi.nlm.nih.gov/17506119/ DOI: 10.1002/dmrr.755","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"HbA1c and fasting glucose","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7dcfa6fe-2d30-59c6-9b62-65ab0425c6be","evidence_kind":"source_excerpt","locator":"Lines 705-716","start_line":705,"end_line":716,"excerpt":"### chromium-biotin-combination-glucose\nFasting glucose changed by −9.8 mg/dL with chromium picolinate plus biotin versus +0.7 mg/dL with placebo (p=0.02).\nCondition category: normal\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The combination also improved fasting glucose in this trial.\norganism: Human with poorly controlled type 2 diabetes\ntissue_or_cell_type: HbA1c and fasting glucose\nexperimental_model: Randomized double-blind placebo-controlled combination trial; 447 enrolled\nlimitations: There were no chromium-only or biotin-only arms. The design cannot identify the active ingredient or prove synergy. Baseline-HbA1c subgroup effects are separately limited.\nexposure: 600 µg Cr(III) as picolinate plus 2 mg biotin/day for 90 days with stable oral diabetes medication\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/17506119.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6e79defd1a4209f869bce07c110f0007d02eda63387c2eadc5e014a04c3fc126\", \"start_char\": 0, \"end_char\": 1739, \"text_sha256\": \"6e79defd1a4209f869bce07c110f0007d02eda63387c2eadc5e014a04c3fc126\"}\n[chromium-p17506119] Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. (2008). https://pubmed.ncbi.nlm.nih.gov/17506119/ DOI: 10.1002/dmrr.755","model_system":"Randomized double-blind placebo-controlled combination trial; 447 enrolled","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chromium-p17506119] Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. 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