{"id":"d2de45b3-f8f9-5ad7-bba0-9195b2fb1990","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-neuro-recovery-incomplete","predicate":"replacement_had_variable_neurologic_recovery","statement":"In 121 adequately followed episodes, all responded and 57 (47.1%) recovered completely; post-treatment involvement was related to pretreatment severity and symptom duration.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"d231451b-3bd1-5a2b-a634-d4072964fb26","mechanism_event_label":"Treatment response and full recovery are different outcomes.","subject":{"id":"b6d9b937-895d-5e0a-8cc5-0454a0b7d373","slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"},"object":{"id":"e058a824-b021-58a0-bcde-d9fb7883b142","slug":"b12-neurologic-recovery","display_name":"Neurologic recovery following B12 replacement","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d231451b-3bd1-5a2b-a634-d4072964fb26","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-neuro-recovery-incomplete-event","event_type":"observed_intervention","label":"Treatment response and full recovery are different outcomes.","description":"In 121 adequately followed episodes, all responded and 57 (47.1%) recovered completely; post-treatment involvement was related to pretreatment severity and symptom duration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b6d9b937-895d-5e0a-8cc5-0454a0b7d373","slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e058a824-b021-58a0-bcde-d9fb7883b142","slug":"b12-neurologic-recovery","display_name":"Neurologic recovery following B12 replacement","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Retrospective clinical series: 153 neurologic B12-deficiency episodes in 143 patients at two New York hospitals over 17 years.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Cobalamin treatment and clinical follow-up; 121 episodes had adequate neurologic response assessment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Related investigators and hospital settings may overlap earlier clinical series. No guaranteed reversibility or universal time limit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Treatment response and full recovery are different outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b12-healton1991] Neurologic aspects of cobalamin deficiency (1991). https://pubmed.ncbi.nlm.nih.gov/1648656/ DOI: 10.1097/00005792-199107000-00001","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"359f93a3-967a-5ee7-a679-84156aa575ba","evidence_kind":"source_excerpt","locator":"Lines 1450-1460","start_line":1450,"end_line":1460,"excerpt":"### b12-neuro-recovery-incomplete\nIn 121 adequately followed episodes, all responded and 57 (47.1%) recovered completely; post-treatment involvement was related to pretreatment severity and symptom duration.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Treatment response and full recovery are different outcomes.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Retrospective clinical series: 153 neurologic B12-deficiency episodes in 143 patients at two New York hospitals over 17 years.\nlimitations: Related investigators and hospital settings may overlap earlier clinical series. No guaranteed reversibility or universal time limit.\nexposure: Cobalamin treatment and clinical follow-up; 121 episodes had adequate neurologic response assessment.\n[b12-healton1991] Neurologic aspects of cobalamin deficiency (1991). https://pubmed.ncbi.nlm.nih.gov/1648656/ DOI: 10.1097/00005792-199107000-00001","model_system":"Retrospective clinical series: 153 neurologic B12-deficiency episodes in 143 patients at two New York hospitals over 17 years.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b12-healton1991] Neurologic aspects of cobalamin deficiency (1991). https://pubmed.ncbi.nlm.nih.gov/1648656/ DOI: 10.1097/00005792-199107000-00001","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73145023-2982-5848-aff2-8d8875d6b9c5","stable_key":"import-7fc92b9e-9cbf-556e-8719-6b5244625250","title":"Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ad5b3a51d36e856aa7fdfd1cc23f690b094689bad87d28e1a621a54675a01c92","revision_id":"118bd616-0c13-549f-bfeb-bc439715b89c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}