{"id":"d2be4a22-4ef1-5684-9b48-9e890d6f0f63","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:severe-mg-deficiency-inadequate-pth-response","predicate":"deficiency-is-associated-with-inadequate","statement":"Most untreated patients in the clinical series had normal or undetectable immunoreactive PTH despite severe hypocalcemia.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"90cf830d-601d-5ece-ba2c-11625564cb9e","mechanism_event_label":"A PTH value within a laboratory reference range can still be too low for someone whose calcium is very low.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"20086ed6-508d-540d-b23d-146f23a8990b","slug":"serum-pth-concentration","display_name":"Serum PTH concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"90cf830d-601d-5ece-ba2c-11625564cb9e","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:severe-mg-deficiency-inadequate-pth-response-event","event_type":"observed_intervention","label":"A PTH value within a laboratory reference range can still be too low for someone whose calcium is very low.","description":"Most untreated patients in the clinical series had normal or undetectable immunoreactive PTH despite severe hypocalcemia.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"role":"low stimulus for compensation","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"measured hormone","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"20086ed6-508d-540d-b23d-146f23a8990b","slug":"serum-pth-concentration","display_name":"Serum PTH concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"magnesium -> PTH -> calcium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human hypomagnesemic hypocalcemia clinical study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational baseline result; older immunoreactive PTH assays differ from modern intact-PTH methods.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A PTH value within a laboratory reference range can still be too low for someone whose calcium is very low.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[rude-1976-human-pth-resistance] Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency (1976). https://pubmed.ncbi.nlm.nih.gov/182417/ DOI: 10.1111/j.1365-2265.1976.tb01947.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood; parathyroid-kidney axis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"669d14a9-4295-50b0-b31d-1a55fb64b0d8","evidence_kind":"source_excerpt","locator":"Lines 301-311","start_line":301,"end_line":311,"excerpt":"### severe-mg-deficiency-inadequate-pth-response\nMost untreated patients in the clinical series had normal or undetectable immunoreactive PTH despite severe hypocalcemia.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A PTH value within a laboratory reference range can still be too low for someone whose calcium is very low.\norganism: Homo sapiens\ntissue_or_cell_type: Blood; parathyroid-kidney axis\nexperimental_model: Human hypomagnesemic hypocalcemia clinical study\nlimitations: Observational baseline result; older immunoreactive PTH assays differ from modern intact-PTH methods.\ncross_nutrient: magnesium -> PTH -> calcium\n[rude-1976-human-pth-resistance] Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency (1976). https://pubmed.ncbi.nlm.nih.gov/182417/ DOI: 10.1111/j.1365-2265.1976.tb01947.x","model_system":"Human hypomagnesemic hypocalcemia clinical study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [rude-1976-human-pth-resistance] Functional hypoparathyroidism and parathyroid hormone end-organ resistance in human magnesium deficiency (1976). https://pubmed.ncbi.nlm.nih.gov/182417/ DOI: 10.1111/j.1365-2265.1976.tb01947.x","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e111c412f57143a17e8e65e74e8f7888b5bb9a61099873f4767f527fac19bb07","revision_id":"6b7f04f2-66ed-5859-955f-c2b50d4bf041","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}