{"id":"d29a56ea-0099-5912-a7d5-74f1b01cecea","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-temperature","predicate":"reduces","statement":"Injected caffeine at 30 mg/kg lowered body temperature, especially in receptor-knockout mice, suggesting an effect beyond A1/A2A blockade.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"b35e31e4-f3e6-5d14-bc68-3780d69538b7","mechanism_event_label":"A higher dose produced effects that the two main receptors did not explain.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"8cf5b3a5-5323-5743-89e3-aeb0abadfc78","slug":"mouse-body-temperature","display_name":"Body temperature in mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b35e31e4-f3e6-5d14-bc68-3780d69538b7","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-temperature-event","event_type":"observed_relationship","label":"A higher dose produced effects that the two main receptors did not explain.","description":"Injected caffeine at 30 mg/kg lowered body temperature, especially in receptor-knockout mice, suggesting an effect beyond A1/A2A blockade.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8cf5b3a5-5323-5743-89e3-aeb0abadfc78","slug":"mouse-body-temperature","display_name":"Body temperature in mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse high-dose injection experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The additional molecular target was not identified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A higher dose produced effects that the two main receptors did not explain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19218506/ · DOI 10.1152/ajpheart.00754.2008","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"21aa2f28-3752-5485-abb8-53eaf1a4f1dc","evidence_kind":"source_excerpt","locator":"Lines 60-66","start_line":60,"end_line":66,"excerpt":"## caf-temperature\nA higher dose produced effects that the two main receptors did not explain.\nInjected caffeine at 30 mg/kg lowered body temperature, especially in receptor-knockout mice, suggesting an effect beyond A1/A2A blockade.\nModel: Mouse high-dose injection experiment.\nLimitations: The additional molecular target was not identified.\nEvidence access: Primary abstract\nPhysiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19218506/ · DOI 10.1152/ajpheart.00754.2008","model_system":"Mouse high-dose injection experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}