{"id":"d2502d06-f032-58ea-b493-4319c90dd281","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-erfe-loss","predicate":"loss_delays","statement":"ERFE-deficient mice failed to suppress hepcidin rapidly after hemorrhage and recovered more slowly from blood loss.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b820bd0e-71c0-5a5c-b71b-62c8ee93f3f3","mechanism_event_label":"The response to blood loss depended on mobilizing stored and absorbed iron.","subject":{"id":"784950b4-f1cb-5579-87e4-43e3e933e638","slug":"mouse-erfe","display_name":"Mouse erythroferrone / Erfe","entity_type_key":"protein"},"object":{"id":"3c926df8-dab4-53f4-bc6c-6e91f283f4d7","slug":"blood-loss-recovery","display_name":"Recovery of erythropoiesis after blood loss","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b820bd0e-71c0-5a5c-b71b-62c8ee93f3f3","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-erfe-loss-event","event_type":"biochemical_relationship","label":"The response to blood loss depended on mobilizing stored and absorbed iron.","description":"ERFE-deficient mice failed to suppress hepcidin rapidly after hemorrhage and recovered more slowly from blood loss.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"784950b4-f1cb-5579-87e4-43e3e933e638","slug":"mouse-erfe","display_name":"Mouse erythroferrone / Erfe","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3c926df8-dab4-53f4-bc6c-6e91f283f4d7","slug":"blood-loss-recovery","display_name":"Recovery of erythropoiesis after blood loss","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iron-research/24880340.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1e290e3082fe90ef8ef538ec8d5151082e3d38672abfba19731ea158957fcc54\", \"start_char\": 0, \"end_char\": 738, \"text_sha256\": \"1e290e3082fe90ef8ef538ec8d5151082e3d38672abfba19731ea158957fcc54\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Hemorrhage, erythropoietin response and gene deletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Blood loss, EPO stimulation and Erfe deletion; thalassemia model","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Stress erythropoiesis and mouse overload mechanisms; the author correction (PMID 32107478; https://doi.org/10.1038/s41588-019-0548-y) corrects swapped human FAM132B and HPRT primer labels in Supplementary Table 2.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The response to blood loss depended on mobilizing stored and absorbed iron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iron-p24880340] Identification of erythroferrone as an erythroid regulator of iron metabolism. 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