{"id":"d236a05a-53e5-5a43-af01-097c3601edcd","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-radiation-scope","predicate":"limits","statement":"FDA guidance limits KI protection to thyroid uptake of radioactive iodine; it does not protect other organs or against other radioactive materials.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"443f3169-e0ea-55ba-95b1-925118a12e3f","mechanism_event_label":"Thyroid blocking is a specific effect, not general radiation protection.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"41f1d3dd-0d28-5e37-808d-7a9b94d370ef","slug":"thyroid-radioiodine-uptake","display_name":"Thyroid radioiodine uptake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"443f3169-e0ea-55ba-95b1-925118a12e3f","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-radiation-scope-event","event_type":"observed_relationship","label":"Thyroid blocking is a specific effect, not general radiation protection.","description":"FDA guidance limits KI protection to thyroid uptake of radioactive iodine; it does not protect other organs or against other radioactive materials.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"41f1d3dd-0d28-5e37-808d-7a9b94d370ef","slug":"thyroid-radioiodine-uptake","display_name":"Thyroid radioiodine uptake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Regulatory guidance on radiation emergencies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Use during an emergency follows public-health direction; not a general supplementation indication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Thyroid blocking is a specific effect, not general radiation protection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"FDA: Frequently Asked Questions on Potassium Iodide · regulatory guidance · https://www.fda.gov/drugs/bioterrorism-and-drug-preparedness/frequently-asked-questions-potassium-iodide-ki","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0a282004-da8e-5ecb-b2aa-e89f98059779","evidence_kind":"source_excerpt","locator":"Lines 472-478","start_line":472,"end_line":478,"excerpt":"## ki-radiation-scope\nThyroid blocking is a specific effect, not general radiation protection.\nFDA guidance limits KI protection to thyroid uptake of radioactive iodine; it does not protect other organs or against other radioactive materials.\nModel: Regulatory guidance on radiation emergencies.\nLimitations: Use during an emergency follows public-health direction; not a general supplementation indication.\nEvidence location: Primary abstract\nFDA: Frequently Asked Questions on Potassium Iodide · regulatory guidance · https://www.fda.gov/drugs/bioterrorism-and-drug-preparedness/frequently-asked-questions-potassium-iodide-ki","model_system":"Regulatory guidance on radiation emergencies.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. 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