{"id":"d1ffbf1c-0ff9-5960-b3e5-6f4005cebefc","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-human-magnesium-sparing-1987","predicate":"reduces","statement":"Boron supplementation reduced urinary magnesium in the 1987 postmenopausal feeding study, apparently more strongly in the low-magnesium group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"76d6cbcc-fa69-5e09-ae05-813ba082a93f","mechanism_event_label":"The measured magnesium loss in urine decreased; this does not by itself demonstrate correction of magnesium deficiency.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"a298b414-0e07-568d-a469-d8aa3e8b8c14","slug":"urinary-magnesium-excretion","display_name":"Urinary magnesium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"76d6cbcc-fa69-5e09-ae05-813ba082a93f","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-human-magnesium-sparing-1987-event","event_type":"observed_intervention","label":"The measured magnesium loss in urine decreased; this does not by itself demonstrate correction of magnesium deficiency.","description":"Boron supplementation reduced urinary magnesium in the 1987 postmenopausal feeding study, apparently more strongly in the low-magnesium group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"dietary_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a298b414-0e07-568d-a469-d8aa3e8b8c14","slug":"urinary-magnesium-excretion","display_name":"Urinary magnesium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/3678698.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8f95ac01b63502b366e2bd79785b7203deb793d258df065f13cc1e0123c89fb7\", \"start_char\": 0, \"end_char\": 1373, \"text_sha256\": \"8f95ac01b63502b366e2bd79785b7203deb793d258df065f13cc1e0123c89fb7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sequential controlled feeding in a metabolic unit; 12 postmenopausal women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"About 0.25 mg boron/day for 119 days, then 3 mg/day supplement; seven low-magnesium and five adequate-magnesium participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small sequential study, not a fracture or bone-density trial. Diet and magnesium status matter. Later studies did not consistently reproduce the reported effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The measured magnesium loss in urine decreased; this does not by itself demonstrate correction of magnesium deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p3678698] Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. 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Diet and magnesium status matter. Later studies did not consistently reproduce the reported effects.\nexposure: About 0.25 mg boron/day for 119 days, then 3 mg/day supplement; seven low-magnesium and five adequate-magnesium participants\nevidence_span: {\"source_cache\": \"artifacts/boron-research/3678698.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8f95ac01b63502b366e2bd79785b7203deb793d258df065f13cc1e0123c89fb7\", \"start_char\": 0, \"end_char\": 1373, \"text_sha256\": \"8f95ac01b63502b366e2bd79785b7203deb793d258df065f13cc1e0123c89fb7\"}\n[boron-p3678698] Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. 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