{"id":"d1ac9b75-c3c6-5377-a2c7-d333c185156a","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-exercise-adaptation","predicate":"attenuates","statement":"In 27 inactive older men training for eight weeks, 250 mg/day trans-resveratrol attenuated gains in maximal oxygen uptake and several cardiovascular/lipid outcomes relative to placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d5e183d5-045b-51f9-be21-49af3d65a740","mechanism_event_label":"Adding a supplement did not necessarily improve the exercise response.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"7fe8265f-5b80-5976-af88-d293e4472b52","slug":"human-older-men-training-cardiovascular-adaptation","display_name":"Cardiovascular adaptation to training in older men","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d5e183d5-045b-51f9-be21-49af3d65a740","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-exercise-adaptation-event","event_type":"observed_relationship","label":"Adding a supplement did not necessarily improve the exercise response.","description":"In 27 inactive older men training for eight weeks, 250 mg/day trans-resveratrol attenuated gains in maximal oxygen uptake and several cardiovascular/lipid outcomes relative to placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7fe8265f-5b80-5976-af88-d293e4472b52","slug":"human-older-men-training-cardiovascular-adaptation","display_name":"Cardiovascular adaptation to training in older men","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"61e08499-3296-56f9-9656-e7263b876637","slug":"trans-resveratrol","display_name":"trans-Resveratrol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized exercise-plus-supplement trial, 14 resveratrol and 13 placebo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence that all exercise benefits disappear or every antioxidant has the same effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Adding a supplement did not necessarily improve the exercise response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23878368/ · DOI 10.1113/jphysiol.2013.258061","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6bcb914f-eaae-5267-90c9-c550ede3c576","evidence_kind":"source_excerpt","locator":"Lines 478-484","start_line":478,"end_line":484,"excerpt":"## resveratrol-exercise-adaptation\nAdding a supplement did not necessarily improve the exercise response.\nIn 27 inactive older men training for eight weeks, 250 mg/day trans-resveratrol attenuated gains in maximal oxygen uptake and several cardiovascular/lipid outcomes relative to placebo.\nModel: Randomized exercise-plus-supplement trial, 14 resveratrol and 13 placebo.\nLimitations: Not evidence that all exercise benefits disappear or every antioxidant has the same effect.\nEvidence access: Primary abstract\nResveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23878368/ · DOI 10.1113/jphysiol.2013.258061","model_system":"Randomized exercise-plus-supplement trial, 14 resveratrol and 13 placebo.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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