{"id":"d182bd0f-ea42-53f0-9242-6df49e2cad6d","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:the-same-cohort-reports-synergy-with-aspirin","predicate":"increases_the_reported_vascular_effect_of","statement":"Co-administration of vitamin K2 and aspirin with nattokinase produced what the authors described as a synergistic effect on the same outcomes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"db6f3162-b29a-5af8-a538-e88a59d56ee4","mechanism_event_label":"Co-administration of vitamin K2 and aspirin with nattokinase produced what the authors described as a synergistic effect on the same outcomes.","subject":{"id":"8ac405bf-3ea0-539a-8e5e-abf503dc7081","slug":"aspirin","display_name":"Aspirin / acetylsalicylic acid","entity_type_key":"drug"},"object":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"db6f3162-b29a-5af8-a538-e88a59d56ee4","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:the-same-cohort-reports-synergy-with-aspirin-event","event_type":"observed_intervention","label":"Co-administration of vitamin K2 and aspirin with nattokinase produced what the authors described as a synergistic effect on the same outcomes.","description":"Carotid artery imaging and blood lipids","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8ac405bf-3ea0-539a-8e5e-abf503dc7081","slug":"aspirin","display_name":"Aspirin / acetylsalicylic acid","entity_type_key":"drug"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"12 months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human (1,062 outpatients)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nattokinase with vitamin K2 and aspirin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A subgroup comparison inside an uncontrolled retrospective study by manufacturer-employed authors, with no formal interaction design. It points the opposite way from the case report in which nattokinase with aspirin preceded a cerebellar hemorrhage, and neither can settle the other.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human (1,062 outpatients)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Co-administration of vitamin K2 and aspirin with nattokinase produced what the authors described as a synergistic effect on the same outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effective management of atherosclerosis progress and hyperlipidemia with nattokinase: A clinical study with 1,062 participants. (2022) https://pubmed.ncbi.nlm.nih.gov/36072877/ DOI: 10.3389/fcvm.2022.964977 Correction on record: Erratum in: Front Cardiovasc Med. 2022 Dec 05;9:1076420. doi: 10.3389/fcvm.2022.1076420. PMID 36545015.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vivo, oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Carotid artery imaging and blood lipids","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"925057f7-95ea-53e6-afdb-2e1d33abc574","evidence_kind":"source_excerpt","locator":"Lines 1170-1170","start_line":1170,"end_line":1170,"excerpt":"Co-administration of vitamin K2 and aspirin with nattokinase produced what the authors described as a synergistic effect on the same outcomes.","model_system":"Human (1,062 outpatients)","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"41cb127c-1c23-53aa-b7d0-5ec7f6fa3c99","stable_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text.","file_path":"","sha256":"34fc46e0e849d06bfa13cb099a79b50679dd6fd0de8a5a0575326afdde3259c1","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[{"id":"30648265-4169-585b-b677-44a8339bb4b0","title":"Nattokinase with aspirin is reported as synergistic benefit and as a bleeding event","kind":"context_difference","status":"open","why":"A retrospective cohort by manufacturer-employed authors reports that co-administering aspirin and vitamin K2 with nattokinase improved carotid and lipid outcomes. A case report describes a cerebellar hemorrhage in a patient on aspirin with cerebral microbleeds after seven days of nattokinase. These are not the same endpoint and cannot refute each other, but they are the entire evidence base on this combination, and they point opposite ways.","resolution":"Unresolved, and unresolvable from these two designs. No formal interaction study exists.","created_at":"2026-09-23 07:55:19","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/30648265-4169-585b-b677-44a8339bb4b0","sides":[{"conflict_id":"30648265-4169-585b-b677-44a8339bb4b0","ordinal":0,"label":"Aspirin with nattokinase improved the reported outcomes","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","start_line":1170,"end_line":1170,"quote":"Co-administration of vitamin K2 and aspirin with nattokinase produced what the authors described as a synergistic effect on the same outcomes.","source_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","source_title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","claim_ids":["d182bd0f-ea42-53f0-9242-6df49e2cad6d"]},{"conflict_id":"30648265-4169-585b-b677-44a8339bb4b0","ordinal":1,"label":"Aspirin with nattokinase preceded a cerebellar hemorrhage","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","start_line":1390,"end_line":1390,"quote":"A patient taking aspirin for secondary stroke prevention had an acute cerebellar hemorrhage after seven consecutive days of nattokinase at 400 mg daily, with multiple cerebral microbleeds on MRI.","source_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","source_title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","claim_ids":["5da84366-cafb-5ecc-ba2a-71270b48227f"]}]}],"corrections":[],"research":null}