{"id":"d15da03a-56de-55c4-b3b4-25665761e388","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-folate-choline-repletion","predicate":"repletion_restores","statement":"Folate repletion returned depressed plasma choline-status measures to baseline or above in the low-choline feeding studies.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"827eef64-9feb-53cd-9b75-ee559a34e7f8","mechanism_event_label":"Restoring folate improved the choline markers.","subject":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"object":{"id":"8e1d19fd-ad66-575d-81c4-9122f78915e5","slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"827eef64-9feb-53cd-9b75-ee559a34e7f8","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-methyl-folate-choline-repletion-event","event_type":"biochemical_relationship","label":"Restoring folate improved the choline markers.","description":"Folate repletion returned depressed plasma choline-status measures to baseline or above in the low-choline feeding studies.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e1d19fd-ad66-575d-81c4-9122f78915e5","slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Folate repletion modifies choline status.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolic-unit depletion/repletion: 11 men, 10 women.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2-6 weeks folic-acid repletion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence folate replaces dietary choline.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Restoring folate improved the choline markers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[jacob-1999] Folate nutriture alters choline status of women and men fed low choline diets (1999). https://pubmed.ncbi.nlm.nih.gov/10082779/ DOI: 10.1093/jn/129.3.712","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"79dc7486-d1fb-5da5-9daa-7437f220a9d5","evidence_kind":"source_excerpt","locator":"Lines 718-729","start_line":718,"end_line":729,"excerpt":"### folate-methyl-folate-choline-repletion\nFolate repletion returned depressed plasma choline-status measures to baseline or above in the low-choline feeding studies.\nCondition category: nutrient_deficiency\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Restoring folate improved the choline markers.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma\nexperimental_model: Metabolic-unit depletion/repletion: 11 men, 10 women.\nlimitations: Not evidence folate replaces dietary choline.\nexposure: 2-6 weeks folic-acid repletion\ncross_nutrient: Folate repletion modifies choline status.\n[jacob-1999] Folate nutriture alters choline status of women and men fed low choline diets (1999). https://pubmed.ncbi.nlm.nih.gov/10082779/ DOI: 10.1093/jn/129.3.712","model_system":"Metabolic-unit depletion/repletion: 11 men, 10 women.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [jacob-1999] Folate nutriture alters choline status of women and men fed low choline diets (1999). https://pubmed.ncbi.nlm.nih.gov/10082779/ DOI: 10.1093/jn/129.3.712","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}