{"id":"d127ccca-820f-5159-b628-cdf40d12dc29","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:rested-cognition","predicate":"context_dependent_observation","statement":"A sixty-man trial found selected memory, planning and inhibitory-control improvements with response slowing on some tasks.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9982a7dc-9ce4-5669-869a-c8ee034febcf","mechanism_event_label":"A sixty-man trial found selected memory, planning and inhibitory-control improvements with response slowing on some tasks.","subject":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"object":{"id":"4497a61f-f047-57b3-8842-8df0ce8d370f","slug":"cognitive-task-performance","display_name":"Cognitive task performance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9982a7dc-9ce4-5669-869a-c8ee034febcf","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:rested-cognition-event","event_type":"experimental_observation","label":"A sixty-man trial found selected memory, planning and inhibitory-control improvements with response slowing on some tasks.","description":"In a 60-man randomized trial, modafinil improved selected memory, planning and inhibitory-control measures, while slowing responses on some tasks. Several other measures—including attentional set shifting—did not significantly improve. Objective benefit and null results belong together. [Turner et al.](https://pubmed.ncbi.nlm.nih.gov/12417966/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Modafinil","sequence_order":0,"notes":""},{"entity":{"id":"4497a61f-f047-57b3-8842-8df0ce8d370f","slug":"cognitive-task-performance","display_name":"Cognitive task performance","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"mixed","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract checked; full methods and figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Modafinil\", \"comparator\": \"Placebo\", \"endpoint\": \"A sixty-man trial found selected memory, planning and inhibitory-control improvements with response slowing on some tasks.\", \"effect_direction\": \"mixed\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Rested human volunteers, randomized trial; selected endpoint improvements do not establish general intelligence enhancement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A sixty-man trial found selected memory, planning and inhibitory-control improvements with response slowing on some tasks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cognitive enhancing effects of modafinil in healthy volunteers. | 2003 | DOI 10.1007/s00213-002-1250-8 | PMID 12417966 | https://pubmed.ncbi.nlm.nih.gov/12417966/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 152-152; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"acc916ec-a88f-58f1-a4b5-46cd13580bde","evidence_kind":"source_excerpt","locator":"Lines 152-152","start_line":152,"end_line":152,"excerpt":"In a 60-man randomized trial, modafinil improved selected memory, planning and inhibitory-control measures, while slowing responses on some tasks. Several other measures—including attentional set shifting—did not significantly improve. Objective benefit and null results belong together. [Turner et al.](https://pubmed.ncbi.nlm.nih.gov/12417966/)","model_system":"Rested human volunteers, randomized trial; selected endpoint improvements do not establish general intelligence enhancement.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"17a64928-eaa2-5117-ba4f-52dcbdf9cc9e","stable_key":"import-6660bba2-4fa0-590a-bf52-9803a24bea9f","title":"Modafinil: detailed mechanisms of action (reviewed 3 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"006008cb4cfd183dd3b0846d3abc66c8ebf40cf1b6bd1f0bcdb4f4d937a8e115","revision_id":"c85b3e2e-c18a-59fc-9e79-5c375e64d119","review_status":"source_recorded","notes":""}}],"relations":[{"id":"e9aa027a-f748-5bd0-8783-ae86eeab547c","relation_type":"limits_scope_of","notes":"The same trial has positive and null outcomes. The positive findings do not establish universal cognitive benefit.","source_claim_id":"7755cb9e-7eae-55db-b453-f41d1bba046e","source_claim_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:setshift-null","source_statement":"Attentional set shifting did not significantly improve in the sixty-man modafinil trial.","target_claim_id":"d127ccca-820f-5159-b628-cdf40d12dc29","target_claim_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:rested-cognition","target_statement":"A sixty-man trial found selected memory, planning and inhibitory-control improvements with response slowing on some tasks."}],"conflicts":[],"corrections":[],"research":null}