{"id":"d0e50be8-d1f9-5c78-a986-db60d705096c","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-lipolysis-feedback","predicate":"inhibits_via_receptor","statement":"D-beta-hydroxybutyrate inhibited mouse adipocyte lipolysis in an Hcar2-dependent manner.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"bfd80fc9-6f99-5f1d-95d5-e8047b28a0a0","mechanism_event_label":"A ketone could feed back on its upstream fuel supply.","subject":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"object":{"id":"609e2bca-5c38-55d5-a4fc-a65e72f98427","slug":"mouse-adipocyte-lipolysis","display_name":"Mouse adipocyte lipolysis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bfd80fc9-6f99-5f1d-95d5-e8047b28a0a0","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-bhb-lipolysis-feedback-event","event_type":"observed_relationship","label":"A ketone could feed back on its upstream fuel supply.","description":"D-beta-hydroxybutyrate inhibited mouse adipocyte lipolysis in an Hcar2-dependent manner.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"59496369-eea6-5302-a0a3-2dcfa8f2b71a","slug":"d-beta-hydroxybutyrate","display_name":"D-(R)-beta-hydroxybutyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"609e2bca-5c38-55d5-a4fc-a65e72f98427","slug":"mouse-adipocyte-lipolysis","display_name":"Mouse adipocyte lipolysis","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c9d27457-988d-5d60-bba4-44e320789996","slug":"mouse-hcar2","display_name":"Mouse Hcar2 / PUMA-G receptor","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse adipocyte experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Whole-body ketone feedback was proposed; magnitude in human fasting was not established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"A ketone could feed back on its upstream fuel supply.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15929991/ · DOI 10.1074/jbc.C500213200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"557bbe49-9fa7-5f63-917a-109c015e81f6","evidence_kind":"source_excerpt","locator":"Lines 360-366","start_line":360,"end_line":366,"excerpt":"## fast-bhb-lipolysis-feedback\nA ketone could feed back on its upstream fuel supply.\nD-beta-hydroxybutyrate inhibited mouse adipocyte lipolysis in an Hcar2-dependent manner.\nModel: Mouse adipocyte experiments.\nLimitations: Whole-body ketone feedback was proposed; magnitude in human fasting was not established.\nEvidence access: Primary abstract\n(D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. · 2005 · https://pubmed.ncbi.nlm.nih.gov/15929991/ · DOI 10.1074/jbc.C500213200","model_system":"Mouse adipocyte experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}