{"id":"d09f59e5-50e5-5bc5-84ce-456d7a7bb06f","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-mouse-pca","predicate":"decreases_in_recorded_comparison","statement":"RA reduced passive cutaneous anaphylaxis and allergic ear edema in the mouse model.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"157b3a0d-4480-54bf-ba7c-4310d49e5218","mechanism_event_label":"RA reduced passive cutaneous anaphylaxis and allergic ear edema in the mouse model.","subject":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"object":{"id":"d195150a-42c0-5283-a742-5459c5949537","slug":"mouse-passive-cutaneous-anaphylaxis","display_name":"Mouse passive cutaneous anaphylaxis","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"157b3a0d-4480-54bf-ba7c-4310d49e5218","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-mouse-pca-event","event_type":"experimental_observation","label":"RA reduced passive cutaneous anaphylaxis and allergic ear edema in the mouse model.","description":"### ra-mouse-pca\n\nRA reduced passive cutaneous anaphylaxis and allergic ear edema in the mouse model.\nSeparate animal endpoint from the rat-cell measurements.\nModel and exposure: Anti-DNP IgE / DNP-HSA challenge; primary abstract.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Inhibitory effect of rosmarinic acid on IgE-trigged mast cell degranulation in vitro and in vivo. | 2024 | https://pubmed.ncbi.nlm.nih.gov/38270683/ | https://doi.org/10.1007/s11033-023-09164-z | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"RA-treated challenge","sequence_order":0,"notes":""},{"entity":{"id":"d195150a-42c0-5283-a742-5459c5949537","slug":"mouse-passive-cutaneous-anaphylaxis","display_name":"Mouse passive cutaneous anaphylaxis","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"RA-treated challenge\", \"comparator\": \"Challenge without RA\", \"endpoint\": \"RA reduced passive cutaneous anaphylaxis and allergic ear edema in the mouse model.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"Anti-DNP IgE / DNP-HSA challenge; primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"RA reduced passive cutaneous anaphylaxis and allergic ear edema in the mouse model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibitory effect of rosmarinic acid on IgE-trigged mast cell degranulation in vitro and in vivo. | https://pubmed.ncbi.nlm.nih.gov/38270683/ | https://doi.org/10.1007/s11033-023-09164-z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-mouse-pca; Separate animal endpoint from the rat-cell measurements.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"eced89d0-02d1-5744-bae7-733bc50f5fb9","evidence_kind":"source_excerpt","locator":"Lines 277-283","start_line":277,"end_line":283,"excerpt":"### ra-mouse-pca\n\nRA reduced passive cutaneous anaphylaxis and allergic ear edema in the mouse model.\nSeparate animal endpoint from the rat-cell measurements.\nModel and exposure: Anti-DNP IgE / DNP-HSA challenge; primary abstract.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Inhibitory effect of rosmarinic acid on IgE-trigged mast cell degranulation in vitro and in vivo. | 2024 | https://pubmed.ncbi.nlm.nih.gov/38270683/ | https://doi.org/10.1007/s11033-023-09164-z | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Anti-DNP IgE / DNP-HSA challenge; primary abstract.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}