{"id":"d09aecbe-ff8a-54dd-83b2-9c26a729c821","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-p5c","predicate":"spontaneously_cyclizes_to","statement":"Glutamate-5-semialdehyde spontaneously cyclizes to P5C.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8da7525b-c90d-5ec5-974e-d915d03f510e","mechanism_event_label":"A separate chemical step links the reaction products.","subject":{"id":"33e6c1dc-af9c-5ec6-8e23-6c15bff974f5","slug":"glutamate-5-semialdehyde","display_name":"L-Glutamate-5-semialdehyde","entity_type_key":"small_molecule"},"object":{"id":"cbf8b66e-3d66-53f0-9c21-bc9c014131e7","slug":"pyrroline-5-carboxylate","display_name":"Delta-1-pyrroline-5-carboxylate / P5C","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"8da7525b-c90d-5ec5-974e-d915d03f510e","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-p5c-event","event_type":"observed_relationship","label":"A separate chemical step links the reaction products.","description":"Glutamate-5-semialdehyde spontaneously cyclizes to P5C.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"33e6c1dc-af9c-5ec6-8e23-6c15bff974f5","slug":"glutamate-5-semialdehyde","display_name":"L-Glutamate-5-semialdehyde","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cbf8b66e-3d66-53f0-9c21-bc9c014131e7","slug":"pyrroline-5-carboxylate","display_name":"Delta-1-pyrroline-5-carboxylate / P5C","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Reaction chemistry described in the human OAT study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This step alone does not demonstrate arginine supplementation improves collagen deposition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A separate chemical step links the reaction products.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Crystal structure of human recombinant ornithine aminotransferase. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9514741/ · DOI 10.1006/jmbi.1997.1583","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1ff56028-4243-5887-890f-0d5334afa67d","evidence_kind":"source_excerpt","locator":"Lines 126-132","start_line":126,"end_line":132,"excerpt":"## arg-p5c\nA separate chemical step links the reaction products.\nGlutamate-5-semialdehyde spontaneously cyclizes to P5C.\nModel: Reaction chemistry described in the human OAT study.\nLimitations: This step alone does not demonstrate arginine supplementation improves collagen deposition.\nEvidence access: Primary abstract\nCrystal structure of human recombinant ornithine aminotransferase. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9514741/ · DOI 10.1006/jmbi.1997.1583","model_system":"Reaction chemistry described in the human OAT study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}