{"id":"d085db7a-1f31-50c3-a9dc-535e808546f4","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-human-dna-marker","predicate":"reduces","statement":"In a 42-woman trial of 0, 2 or 8 mg/day for eight weeks, astaxanthin reduced a DNA-damage biomarker by week four; lipid peroxidation did not decrease.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"64deab41-6dd7-5438-9319-bc92f8fa77ac","mechanism_event_label":"One damage marker improved while another did not.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"06cfc379-2b27-5963-975e-806fb506d142","slug":"human-astaxanthin-dna-damage","display_name":"Human DNA-damage biomarker response to astaxanthin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"64deab41-6dd7-5438-9319-bc92f8fa77ac","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-human-dna-marker-event","event_type":"observed_relationship","label":"One damage marker improved while another did not.","description":"In a 42-woman trial of 0, 2 or 8 mg/day for eight weeks, astaxanthin reduced a DNA-damage biomarker by week four; lipid peroxidation did not decrease.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"06cfc379-2b27-5963-975e-806fb506d142","slug":"human-astaxanthin-dna-damage","display_name":"Human DNA-damage biomarker response to astaxanthin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized study of young women; 14 participants per arm.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small trial with multiple endpoints; no cancer-prevention or infection outcome was established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"One damage marker improved while another did not.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20205737/ · DOI 10.1186/1743-7075-7-18","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"21b39d19-5876-59ef-8860-d134a2e3c68f","evidence_kind":"source_excerpt","locator":"Lines 390-396","start_line":390,"end_line":396,"excerpt":"## astaxanthin-human-dna-marker\nOne damage marker improved while another did not.\nIn a 42-woman trial of 0, 2 or 8 mg/day for eight weeks, astaxanthin reduced a DNA-damage biomarker by week four; lipid peroxidation did not decrease.\nModel: Randomized study of young women; 14 participants per arm.\nLimitations: Small trial with multiple endpoints; no cancer-prevention or infection outcome was established.\nEvidence access: Primary abstract\nAstaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20205737/ · DOI 10.1186/1743-7075-7-18","model_system":"Randomized study of young women; 14 participants per arm.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}