{"id":"cfdda418-d511-5369-9b8a-0b7cb59943f3","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:rat-phosphate","predicate":"increases_in_recorded_comparison","statement":"ALCAR treatment reversed reduced phosphate-carrier activity in aged rat heart mitochondria.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0d970897-93a5-5cec-8190-b529d12cf170","mechanism_event_label":"ALCAR treatment reversed reduced phosphate-carrier activity in aged rat heart mitochondria.","subject":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"object":{"id":"50657f07-5c03-5e96-bc53-9937972871e4","slug":"rat-aged-heart-phosphate-transport","display_name":"Aged-rat mitochondrial phosphate-carrier activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0d970897-93a5-5cec-8190-b529d12cf170","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:rat-phosphate-event","event_type":"experimental_observation","label":"ALCAR treatment reversed reduced phosphate-carrier activity in aged rat heart mitochondria.","description":"### rat-phosphate\n\nALCAR treatment reversed reduced phosphate-carrier activity in aged rat heart mitochondria.\nCardiolipin-mediated explanation was proposed; these observations do not establish a direct ALCAR cardiolipin-remodeling enzyme reaction or human cardiac benefit.\nModel and exposure: Aged-rat heart mitochondrial preparation; indexed primary abstract, dose/time not extracted.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: The effect of aging and acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria. | 1992 | https://pubmed.ncbi.nlm.nih.gov/1543717/ | https://doi.org/10.1016/0005-2736(92)90103-s | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"ALCAR treatment of aged rats","sequence_order":0,"notes":""},{"entity":{"id":"50657f07-5c03-5e96-bc53-9937972871e4","slug":"rat-aged-heart-phosphate-transport","display_name":"Aged-rat mitochondrial phosphate-carrier activity","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"ALCAR treatment of aged rats\", \"comparator\": \"Untreated aged rats\", \"endpoint\": \"ALCAR treatment reversed reduced phosphate-carrier activity in aged rat heart mitochondria.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Aged-rat heart mitochondrial preparation; indexed primary abstract, dose/time not extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived curation with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetyl-L-carnitine collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"ALCAR treatment reversed reduced phosphate-carrier activity in aged rat heart mitochondria.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of aging and acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria. | https://pubmed.ncbi.nlm.nih.gov/1543717/ | https://doi.org/10.1016/0005-2736(92)90103-s","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference rat-phosphate; Cardiolipin-mediated explanation was proposed; these observations do not establish a direct ALCAR cardiolipin-remodeling enzyme reaction or human cardiac benefit.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"62554ec6-3390-52c7-af3d-3766af559cfc","evidence_kind":"source_excerpt","locator":"Lines 420-426","start_line":420,"end_line":426,"excerpt":"### rat-phosphate\n\nALCAR treatment reversed reduced phosphate-carrier activity in aged rat heart mitochondria.\nCardiolipin-mediated explanation was proposed; these observations do not establish a direct ALCAR cardiolipin-remodeling enzyme reaction or human cardiac benefit.\nModel and exposure: Aged-rat heart mitochondrial preparation; indexed primary abstract, dose/time not extracted.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: The effect of aging and acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria. | 1992 | https://pubmed.ncbi.nlm.nih.gov/1543717/ | https://doi.org/10.1016/0005-2736(92)90103-s | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Aged-rat heart mitochondrial preparation; indexed primary abstract, dose/time not extracted.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2588f904-245a-597a-8a12-65118013fb90","stable_key":"import-e3f6ce02-0bd7-5103-acc1-68503ab6751b","title":"Acetyl-L-carnitine: detailed mechanisms of action (reviewed 6 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original review of primary studies and clearly identified official records. Exact primary access is stated; no independent replication is claimed.","file_path":"","sha256":"84cc82d6fbb0fd5d73c4ce779e9f88e7f0184ba2d29b18ad0f153815380f2975","revision_id":"dac7a950-dbe5-5c7a-9c70-2ea711d5c71a","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}