{"id":"cfb9d9e0-ae6e-52e5-962a-d5d2c10ce8fb","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-glycated-transferrin-delivery","predicate":"reduces","statement":"Glycated transferrin retained two chromium-binding equivalents but had altered spectroscopic behavior and greatly reduced chromium delivery in rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a00c5fc9-0af9-5ae6-b635-208536287e18","mechanism_event_label":"A carrier can still bind the metal yet distribute it less effectively.","subject":{"id":"28cd8e7c-22ad-5171-8593-4921a14a9344","slug":"experimental-glycated-transferrin","display_name":"Experimentally glycated transferrin (species not specified in indexed abstract)","entity_type_key":"protein_state"},"object":{"id":"7a1b6ac0-4de1-5615-9a52-13809e20a6d8","slug":"tissue-chromium-delivery","display_name":"Delivery of chromium to tissues","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a00c5fc9-0af9-5ae6-b635-208536287e18","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-glycated-transferrin-delivery-event","event_type":"biochemical_relationship","label":"A carrier can still bind the metal yet distribute it less effectively.","description":"Glycated transferrin retained two chromium-binding equivalents but had altered spectroscopic behavior and greatly reduced chromium delivery in rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d160bdf-c463-5f93-9e50-137f41a1f369","slug":"chromium-iii","display_name":"Trivalent chromium / Cr(III)","entity_type_key":"ion"},"role":"transported_metal","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"28cd8e7c-22ad-5171-8593-4921a14a9344","slug":"experimental-glycated-transferrin","display_name":"Experimentally glycated transferrin (species not specified in indexed abstract)","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7a1b6ac0-4de1-5615-9a52-13809e20a6d8","slug":"tissue-chromium-delivery","display_name":"Delivery of chromium to tissues","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/27592288.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"541c9ba554cad6d899569dc16cdd68b1125542e2df006cb50db19f66d6e78d09\", \"start_char\": 0, \"end_char\": 1460, \"text_sha256\": \"541c9ba554cad6d899569dc16cdd68b1125542e2df006cb50db19f66d6e78d09\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Transferrin incubation, metal binding and rat delivery experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Transferrin stored at 37°C with or without glucose before chromium binding and delivery assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Protein storage itself altered binding. The glycated-protein result does not establish chromium deficiency in human diabetes or a treatment response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Purified transferrin and rat in-vivo transport","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A carrier can still bind the metal yet distribute it less effectively.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p27592288] The effects of the glycation of transferrin on chromium binding and the transport and distribution of chromium in vivo. (2016). https://pubmed.ncbi.nlm.nih.gov/27592288/ DOI: 10.1016/j.jinorgbio.2016.08.008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Carrier protein and systemic chromium distribution","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"a644e944-e0d1-59b9-9f3c-0f960f2d53f5","evidence_kind":"source_excerpt","locator":"Lines 471-482","start_line":471,"end_line":482,"excerpt":"### chromium-glycated-transferrin-delivery\nGlycated transferrin retained two chromium-binding equivalents but had altered spectroscopic behavior and greatly reduced chromium delivery in rats.\nCondition category: machinery_impairment\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A carrier can still bind the metal yet distribute it less effectively.\norganism: Purified transferrin and rat in-vivo transport\ntissue_or_cell_type: Carrier protein and systemic chromium distribution\nexperimental_model: Transferrin incubation, metal binding and rat delivery experiments\nlimitations: Protein storage itself altered binding. The glycated-protein result does not establish chromium deficiency in human diabetes or a treatment response.\nexposure: Transferrin stored at 37°C with or without glucose before chromium binding and delivery assays\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/27592288.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"541c9ba554cad6d899569dc16cdd68b1125542e2df006cb50db19f66d6e78d09\", \"start_char\": 0, \"end_char\": 1460, \"text_sha256\": \"541c9ba554cad6d899569dc16cdd68b1125542e2df006cb50db19f66d6e78d09\"}\n[chromium-p27592288] The effects of the glycation of transferrin on chromium binding and the transport and distribution of chromium in vivo. (2016). https://pubmed.ncbi.nlm.nih.gov/27592288/ DOI: 10.1016/j.jinorgbio.2016.08.008","model_system":"Transferrin incubation, metal binding and rat delivery experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chromium-p27592288] The effects of the glycation of transferrin on chromium binding and the transport and distribution of chromium in vivo. (2016). https://pubmed.ncbi.nlm.nih.gov/27592288/ DOI: 10.1016/j.jinorgbio.2016.08.008","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa96342a-ca01-5425-98d9-d50e29bf0abd","stable_key":"import-4d8e4781-3878-5818-8d0a-7dbd6e024555","title":"Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"6cae22f9104c6de041b25c23b0fd2884cc57707ac0c9a87c20b0e665d16de5ab","revision_id":"22893798-8329-5295-9c9d-82169032fc79","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}