{"id":"cf116dcc-56eb-5984-98c3-29757e37f563","stable_key":"10629adf-a816-5b7b-82db-a76bfbb946f2:bg-a-claim-with-conditions","predicate":"reduces","statement":"Most of the 16 human intervention studies considered pertinent for the scientific substantiation of the claim showed that oat beta-glucans reduce postprandial blood glucose peaks when consumed as part of foods or meals rich in available carbohydrates, the Panel also took into account that oat beta-glucans did not increase postprandial glycaemic or insulinaemic responses and that the mechanism by which consumption could exert the claimed effect is well established, and the Panel concludes that a cause-and-effect relationship has been established, with foods or meals required to contain at least 30 grams of available carbohydrates per portion and at least 3 grams of beta-glucans from oats for each 30 grams of available carbohydrates in order to bear the claim.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"765ecf3f-f20d-5758-8972-65c5e34adbdc","mechanism_event_label":"A regulator accepted the effect on the glucose peak, and attached an exact amount and an exact kind of meal to it.","subject":{"id":"fa30a72e-ed34-59eb-badd-236561a8db88","slug":"oat-beta-glucan","display_name":"Oat mixed-linkage beta-(1->3)/(1->4)-glucan","entity_type_key":"chemical_species"},"object":{"id":"3e937170-4281-5ac9-9e3c-09154c700c8e","slug":"glucose-peak-rise","display_name":"Postprandial glucose incremental peak rise","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"765ecf3f-f20d-5758-8972-65c5e34adbdc","stable_key":"10629adf-a816-5b7b-82db-a76bfbb946f2:bg-a-claim-with-conditions-event","event_type":"observed_intervention","label":"A regulator accepted the effect on the glucose peak, and attached an exact amount and an exact kind of meal to it.","description":"Most of the 16 human intervention studies considered pertinent for the scientific substantiation of the claim showed that oat beta-glucans reduce postprandial blood glucose peaks when consumed as part of foods or meals rich in available carbohydrates, the Panel also took into account that oat beta-glucans did not increase postprandial glycaemic or insulinaemic responses and that the mechanism by which consumption could exert the claimed effect is well established, and the Panel concludes that a cause-and-effect relationship has been established, with foods or meals required to contain at least 30 grams of available carbohydrates per portion and at least 3 grams of beta-glucans from oats for each 30 grams of available carbohydrates in order to bear the claim.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"264438cb-3c0e-5ff2-99f3-c486300e5b18","slug":"authorised-health-claim","display_name":"An authorised European health claim and its conditions of use","entity_type_key":"cellular_process"},"role":"regulatory_instrument","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"62869c3c-d84c-504e-a8d9-5decdee892d2","slug":"glucose-iauc","display_name":"Postprandial glucose incremental area under the curve","entity_type_key":"cellular_process"},"role":"related_measure","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fa30a72e-ed34-59eb-badd-236561a8db88","slug":"oat-beta-glucan","display_name":"Oat mixed-linkage beta-(1->3)/(1->4)-glucan","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3e937170-4281-5ac9-9e3c-09154c700c8e","slug":"glucose-peak-rise","display_name":"Postprandial glucose incremental peak rise","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/glucan-research/41726114.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"22ad4a8c479116e3d7130ddcda6f561239dc9b2048d52e29279e48bac6799a3e\", \"start_char\": 0, \"end_char\": 1617, \"text_sha256\": \"22ad4a8c479116e3d7130ddcda6f561239dc9b2048d52e29279e48bac6799a3e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"European Food Safety Authority assessment of 16 human intervention studies for a new health claim","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oat beta-glucans consumed as part of foods or meals rich in available carbohydrates","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A regulatory opinion that weighs an evidence base and sets conditions of use. Authorisation is a separate legal step, and the claim applies only under the stated conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair.","comparator":null,"unit":null,"notes":"","entity":{"slug":"beta-glucan","display_name":"Beta-glucan","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A regulator accepted the effect on the glucose peak, and attached an exact amount and an exact kind of meal to it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[bg-p41726114] Oat beta-glucans and reduction of postprandial glucose peak: Evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006. (2026). https://pubmed.ncbi.nlm.nih.gov/41726114/ DOI: 10.2903/j.efsa.2026.9942","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Postprandial circulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cf87f4a3-76fa-5f90-a0da-85220be0c64d","evidence_kind":"source_excerpt","locator":"Lines 606-617","start_line":606,"end_line":617,"excerpt":"### bg-a-claim-with-conditions\nMost of the 16 human intervention studies considered pertinent for the scientific substantiation of the claim showed that oat beta-glucans reduce postprandial blood glucose peaks when consumed as part of foods or meals rich in available carbohydrates, the Panel also took into account that oat beta-glucans did not increase postprandial glycaemic or insulinaemic responses and that the mechanism by which consumption could exert the claimed effect is well established, and the Panel concludes that a cause-and-effect relationship has been established, with foods or meals required to contain at least 30 grams of available carbohydrates per portion and at least 3 grams of beta-glucans from oats for each 30 grams of available carbohydrates in order to bear the claim.\nCondition category: normal\nnutrient_topic: Beta-glucan research collection; topical membership is not evidence of a direct clinical effect, and each preparation is recorded as its own entity with no family link joining any pair.\nplain_language: A regulator accepted the effect on the glucose peak, and attached an exact amount and an exact kind of meal to it.\norganism: Human\ntissue_or_cell_type: Postprandial circulation\nexperimental_model: European Food Safety Authority assessment of 16 human intervention studies for a new health claim\nlimitations: A regulatory opinion that weighs an evidence base and sets conditions of use. Authorisation is a separate legal step, and the claim applies only under the stated conditions.\nexposure: Oat beta-glucans consumed as part of foods or meals rich in available carbohydrates\nevidence_span: {\"source_cache\": \"artifacts/glucan-research/41726114.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"22ad4a8c479116e3d7130ddcda6f561239dc9b2048d52e29279e48bac6799a3e\", \"start_char\": 0, \"end_char\": 1617, \"text_sha256\": \"22ad4a8c479116e3d7130ddcda6f561239dc9b2048d52e29279e48bac6799a3e\"}\n[bg-p41726114] Oat beta-glucans and reduction of postprandial glucose peak: Evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006. (2026). https://pubmed.ncbi.nlm.nih.gov/41726114/ DOI: 10.2903/j.efsa.2026.9942","model_system":"European Food Safety Authority assessment of 16 human intervention studies for a new health claim","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [bg-p41726114] Oat beta-glucans and reduction of postprandial glucose peak: Evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006. (2026). https://pubmed.ncbi.nlm.nih.gov/41726114/ DOI: 10.2903/j.efsa.2026.9942","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"74dc223d-8289-57bf-a731-d220fa017c1e","stable_key":"import-10629adf-a816-5b7b-82db-a76bfbb946f2","title":"Beta-glucan: a structural family rather than an agent, what decides whether a bound glucan actually signals, the complement route that a cereal and a yeast preparation share, and the unequal human evidence behind each (2026-09-22)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"7c62f2d2f8d99b650e6dc26a505b0f053ae1c8bdb38099d4dfc0771f65287461","revision_id":"a53bb794-0a4b-525d-9cf7-22b46a5403b0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}