{"id":"cf07e92e-a744-5fca-b1e3-090138a5df97","stable_key":"08ce9896-9d1c-5bbf-b705-5bfe771091d5:b7-lactation-bisnor","predicate":"has_context_dependent_turnover_marker","statement":"Lactating women excreted 76% more bisnorbiotin than controls, while 3-HIA and 3-HIA-carnitine excretion were lower.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7e839f67-6111-5d27-ad43-6cb18ec5ce34","mechanism_event_label":"Biotin breakdown and leucine-derived markers can diverge during lactation.","subject":{"id":"37a8e96b-f95b-5ba7-a0bc-8ed3cfaf5fd8","slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"},"object":{"id":"26996c51-7052-5890-b527-ae183183274b","slug":"human-urinary-bisnorbiotin","display_name":"Human urinary bisnorbiotin excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7e839f67-6111-5d27-ad43-6cb18ec5ce34","stable_key":"08ce9896-9d1c-5bbf-b705-5bfe771091d5:b7-lactation-bisnor-event","event_type":"observed_intervention","label":"Biotin breakdown and leucine-derived markers can diverge during lactation.","description":"Lactating women excreted 76% more bisnorbiotin than controls, while 3-HIA and 3-HIA-carnitine excretion were lower.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e9378f0-3a73-5891-8afd-22825626c94c","slug":"bisnorbiotin","display_name":"Bisnorbiotin","entity_type_key":"small_molecule"},"role":"biotin catabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f707c753-cc8c-5f06-90be-bb3d73c60a18","slug":"leucine","display_name":"L-Leucine","entity_type_key":"small_molecule"},"role":"marker precursor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"37a8e96b-f95b-5ba7-a0bc-8ed3cfaf5fd8","slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"26996c51-7052-5890-b527-ae183183274b","slug":"human-urinary-bisnorbiotin","display_name":"Human urinary bisnorbiotin excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/biotin-research/25122647.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6066b007a013c3c0c69336e7aba0e51baa39e3a24b6eb918cb4778e792376a9b\", \"start_char\": 0, \"end_char\": 2354, \"text_sha256\": \"6066b007a013c3c0c69336e7aba0e51baa39e3a24b6eb918cb4778e792376a9b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled feeding: 26 pregnant, 28 lactating and 21 control women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"57 micrograms dietary biotin per day for 10–12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Groups differed in reproductive state. Marker changes do not establish fetal outcomes, universal deficiency or a treatment dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Biotin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Biotin breakdown and leucine-derived markers can diverge during lactation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b7-p25122647] Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet. 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Marker changes do not establish fetal outcomes, universal deficiency or a treatment dose.\nexposure: 57 micrograms dietary biotin per day for 10–12 weeks\nevidence_span: {\"source_cache\": \"artifacts/biotin-research/25122647.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6066b007a013c3c0c69336e7aba0e51baa39e3a24b6eb918cb4778e792376a9b\", \"start_char\": 0, \"end_char\": 2354, \"text_sha256\": \"6066b007a013c3c0c69336e7aba0e51baa39e3a24b6eb918cb4778e792376a9b\"}\n[b7-p25122647] Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet. (2014). https://pubmed.ncbi.nlm.nih.gov/25122647/ DOI: 10.3945/jn.114.194472","model_system":"Controlled feeding: 26 pregnant, 28 lactating and 21 control women","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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