{"id":"cef9d672-108f-5e3d-a1d3-3ad273bc79c9","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-endothelial-catalase","predicate":"increases_expression","statement":"Ergothioneine increased catalase expression in human brain microvascular endothelial cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"741e8306-8168-5390-9fe0-1f51ffbfde74","mechanism_event_label":"Peroxide-removing machinery was part of the response.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"a95fd25e-3d30-5ece-a735-74ab7fede31f","slug":"human-cat","display_name":"Human catalase / CAT","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"741e8306-8168-5390-9fe0-1f51ffbfde74","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-endothelial-catalase-event","event_type":"observed_relationship","label":"Peroxide-removing machinery was part of the response.","description":"Ergothioneine increased catalase expression in human brain microvascular endothelial cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a95fd25e-3d30-5ece-a735-74ab7fede31f","slug":"human-cat","display_name":"Human catalase / CAT","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cultured human endothelial cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence that ergothioneine supplies heme or iron.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Peroxide-removing machinery was part of the response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Uptake and protective effects of ergothioneine in human endothelial cells. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25022513/ · DOI 10.1124/jpet.114.214049","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fec4edb0-beb7-5db1-ad26-8e0e4f6daf72","evidence_kind":"source_excerpt","locator":"Lines 304-310","start_line":304,"end_line":310,"excerpt":"## ergothioneine-endothelial-catalase\nPeroxide-removing machinery was part of the response.\nErgothioneine increased catalase expression in human brain microvascular endothelial cells.\nModel: Cultured human endothelial cells.\nLimitations: Not evidence that ergothioneine supplies heme or iron.\nEvidence access: Primary abstract\nUptake and protective effects of ergothioneine in human endothelial cells. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25022513/ · DOI 10.1124/jpet.114.214049","model_system":"Cultured human endothelial cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}