{"id":"ce717bfd-daf8-59ed-8b75-2919882627be","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-mouse-optical-clearing","predicate":"increases","statement":"Topical tartrazine produced reversible optical clearing in live-mouse imaging experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"04aac3e5-1ab9-5451-a07c-85309a6ad3c3","mechanism_event_label":"Topical tartrazine produced reversible optical clearing in live-mouse imaging experiments.","subject":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"object":{"id":"16b4a8d7-111d-5319-be16-e9f6a97dbc68","slug":"mouse-topical-tartrazine-transparency","display_name":"Reversible optical transparency of topically treated mouse tissue","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"04aac3e5-1ab9-5451-a07c-85309a6ad3c3","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-mouse-optical-clearing-event","event_type":"observed_relationship","label":"Topical tartrazine produced reversible optical clearing in live-mouse imaging experiments.","description":"Topical tartrazine produced reversible optical clearing in live-mouse imaging experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"16b4a8d7-111d-5319-be16-e9f6a97dbc68","slug":"mouse-topical-tartrazine-transparency","display_name":"Reversible optical transparency of topically treated mouse tissue","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Tartrazine sodium salt 18-30% w/w in agarose gel","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Visible clearing at approximately 5 min; reversible with water rinsing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific experimental curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Live anesthetized mice from several strains in imaging experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Concentrated experimental topical exposure; human efficacy and long-term safety are not established. Does not imply that consuming food dye makes tissue transparent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Live anesthetized mice from several strains in imaging experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Topical tartrazine produced reversible optical clearing in live-mouse imaging experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Achieving optical transparency in live animals with absorbing molecules. (2024). https://pubmed.ncbi.nlm.nih.gov/39236186/ DOI: 10.1126/science.adm6869","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Topical application to depilated skin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Scalp, abdominal skin and hindlimb imaging","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8f421301-1a36-5bd4-a688-f2ca405f68cb","evidence_kind":"source_excerpt","locator":"Lines 446-455","start_line":446,"end_line":455,"excerpt":"## tartrazine-mouse-optical-clearing\nTopical tartrazine produced reversible optical clearing in live-mouse imaging experiments.\nModel/species: Live anesthetized mice from several strains in imaging experiments\nTissue: Scalp, abdominal skin and hindlimb imaging\nExposure: Tartrazine sodium salt 18-30% w/w in agarose gel\nRoute: Topical application to depilated skin\nDuration: Visible clearing at approximately 5 min; reversible with water rinsing\nLimits: Concentrated experimental topical exposure; human efficacy and long-term safety are not established. Does not imply that consuming food dye makes tissue transparent.\nPrimary reference: Achieving optical transparency in live animals with absorbing molecules. (2024). https://pubmed.ncbi.nlm.nih.gov/39236186/ DOI: 10.1126/science.adm6869\nAccess: Primary full-text methods/results and metadata.","model_system":"Live anesthetized mice from several strains in imaging experiments","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; primary citation retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d9540941-68b4-5a0d-a5c1-828665a918e2","stable_key":"import-792249b7-a38d-5f43-afb6-2936818a3fa2","title":"Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text.","file_path":"","sha256":"b83a0113a4b743adc91c24504e488f47e10665386b299c4cb0543da8948f4246","revision_id":"3769070e-6af4-5b02-9d8e-f23c84edba1b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}