{"id":"ce0f97e4-da0b-5cef-acfa-43bdef65b12e","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-gut-deficiency-mucin","predicate":"when_deficient_reduces","statement":"Feeding neonatal piglets 0.1 rather than 0.6 g threonine/kg/day for eight days reduced colonic mucosal mass and mucin content and altered acidic mucin-producing goblet cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e04fa8b8-3d6c-577c-a0e7-02c8f1bf5127","mechanism_event_label":"A severe shortfall changed both mucus quantity and its distribution.","subject":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"object":{"id":"ca131a51-1320-5cea-a2e1-28a4c510903e","slug":"pig-intestinal-mucin-barrier","display_name":"Neonatal pig intestinal mucin barrier","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e04fa8b8-3d6c-577c-a0e7-02c8f1bf5127","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-gut-deficiency-mucin-event","event_type":"observed_relationship","label":"A severe shortfall changed both mucus quantity and its distribution.","description":"Feeding neonatal piglets 0.1 rather than 0.6 g threonine/kg/day for eight days reduced colonic mucosal mass and mucin content and altered acidic mucin-producing goblet cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ca131a51-1320-5cea-a2e1-28a4c510903e","slug":"pig-intestinal-mucin-barrier","display_name":"Neonatal pig intestinal mucin barrier","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Two-day-old piglets; intragastric adequate versus deficient diets.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acidic mucin subtypes decreased in small intestine but increased in colon; these different sites must not be collapsed into one uniform response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A severe shortfall changed both mucus quantity and its distribution.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Adequate oral threonine is critical for mucin production and gut function in neonatal piglets. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17234895/ · DOI 10.1152/ajpgi.00221.2006","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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