{"id":"cddf63af-e35a-55c1-8b38-6f3803cb007c","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-cancer-cohort","predicate":"associated_with","statement":"In 102,865 adults followed a median 7.8 years, higher aspartame consumers had an adjusted overall-cancer hazard ratio of 1.15 versus nonconsumers, 95% CI 1.03–1.28.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"278e4d18-ed2e-5629-919a-a6c606f0ef8a","mechanism_event_label":"An observational association is a discovery lead rather than a proven causal chain.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"89b85ce5-3e96-53e2-ae33-60eb96f568df","slug":"human-aspartame-cancer-cohort-association","display_name":"Human aspartame/cancer association in NutriNet-Sante","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"278e4d18-ed2e-5629-919a-a6c606f0ef8a","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-cancer-cohort-event","event_type":"observed_relationship","label":"An observational association is a discovery lead rather than a proven causal chain.","description":"In 102,865 adults followed a median 7.8 years, higher aspartame consumers had an adjusted overall-cancer hazard ratio of 1.15 versus nonconsumers, 95% CI 1.03–1.28.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"89b85ce5-3e96-53e2-ae33-60eb96f568df","slug":"human-aspartame-cancer-cohort-association","display_name":"Human aspartame/cancer association in NutriNet-Sante","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective dietary-record cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Residual confounding, selection and reverse causality remain possible; no molecular mediator was established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An observational association is a discovery lead rather than a proven causal chain.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35324894/ · DOI 10.1371/journal.pmed.1003950","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"411465b3-7123-5156-a160-27148263b4f3","evidence_kind":"source_excerpt","locator":"Lines 346-352","start_line":346,"end_line":352,"excerpt":"## aspartame-cancer-cohort\nAn observational association is a discovery lead rather than a proven causal chain.\nIn 102,865 adults followed a median 7.8 years, higher aspartame consumers had an adjusted overall-cancer hazard ratio of 1.15 versus nonconsumers, 95% CI 1.03–1.28.\nModel: Prospective dietary-record cohort.\nLimitations: Residual confounding, selection and reverse causality remain possible; no molecular mediator was established.\nEvidence access: Primary abstract\nArtificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35324894/ · DOI 10.1371/journal.pmed.1003950","model_system":"Prospective dietary-record cohort.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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