{"id":"cddbabb0-7b03-5a89-a98b-6f42756846df","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-starvation-p53","predicate":"when_withdrawn_triggers","statement":"Serine withdrawal induced a transient p53–p21 arrest that redirected limited serine toward glutathione synthesis and preserved antioxidant capacity in the tested human cancer cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1de4ffe2-9611-5422-b675-f359099952f8","mechanism_event_label":"Cells can reallocate scarce substrate to survival rather than proliferation.","subject":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"object":{"id":"266128f2-e5bf-5786-8ef7-729a29ed9f99","slug":"human-p53-serine-stress-adaptation","display_name":"p53-dependent adaptation to serine starvation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1de4ffe2-9611-5422-b675-f359099952f8","stable_key":"649e861b-265a-5912-bc36-3a73e53ef892:l-serine-starvation-p53-event","event_type":"observed_relationship","label":"Cells can reallocate scarce substrate to survival rather than proliferation.","description":"Serine withdrawal induced a transient p53–p21 arrest that redirected limited serine toward glutathione synthesis and preserved antioxidant capacity in the tested human cancer cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c882cd0b-9d83-5b07-bd1c-fe4d45657dcb","slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"266128f2-e5bf-5786-8ef7-729a29ed9f99","slug":"human-p53-serine-stress-adaptation","display_name":"p53-dependent adaptation to serine starvation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cancer-cell starvation with p53 comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The response depends on genotype and experimental conditions, not a universal ranking of serine uses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Serine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-serine","display_name":"L-Serine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Cells can reallocate scarce substrate to survival rather than proliferation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23242140/ · DOI 10.1038/nature11743","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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