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(2001). https://pubmed.ncbi.nlm.nih.gov/11375349/ DOI: 10.2337/diabetes.50.6.1464","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"L6 myotubes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"99ce72e8-21b4-58b1-9e18-16ac43bb0e7c","evidence_kind":"source_excerpt","locator":"Lines 923-934","start_line":923,"end_line":934,"excerpt":"### ala-p38-uptake-localization\np38 inhibitors reduced lipoic-acid-stimulated glucose uptake without blocking GLUT4 translocation in L6 myotubes.\nCondition category: normal\nnutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Transporter location and actual glucose movement were separable measurements.\norganism: Rat\ntissue_or_cell_type: L6 myotubes\nexperimental_model: Signaling, transporter localization and glucose-uptake assays\nlimitations: High cell-culture exposure; pharmacological inhibitors can have off-target effects; not a plasma target or patient dose.\nexposure: 2.5 mmol/L lipoic acid; PI3K and p38 inhibitors\nevidence_span: {\"source_cache\": \"artifacts/ala-research/11375349.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"971e4224c0ff09f05d25fe64359a3c65d50f2187fd781840c55821c47d2ed111\", \"start_char\": 0, \"end_char\": 1734, \"text_sha256\": \"971e4224c0ff09f05d25fe64359a3c65d50f2187fd781840c55821c47d2ed111\"}\n[ala-p11375349] The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. 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