{"id":"cdb67352-ed37-53ec-8e3d-852054f5d05b","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-mri-responder-analysis","predicate":"associated_with_in_subgroup","statement":"Eight participants had faster emptying with MSG; two slowed. Duodenal wall-motion analysis in four of the eight showed increased motility.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3917da58-bbf3-5973-81ac-c3894afbd34f","mechanism_event_label":"A selected subgroup can suggest a mechanism without establishing a population effect.","subject":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"object":{"id":"35b9cf1a-a301-59e9-93c0-bd0787ebf64d","slug":"human-msg-selected-mri-responders","display_name":"Selected responders in human MSG MRI study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3917da58-bbf3-5973-81ac-c3894afbd34f","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-mri-responder-analysis-event","event_type":"observed_relationship","label":"A selected subgroup can suggest a mechanism without establishing a population effect.","description":"Eight participants had faster emptying with MSG; two slowed. Duodenal wall-motion analysis in four of the eight showed increased motility.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"35b9cf1a-a301-59e9-93c0-bd0787ebf64d","slug":"human-msg-selected-mri-responders","display_name":"Selected responders in human MSG MRI study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text; results and disclosures","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same ten-person MRI experiment; subgroup analyses.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Responder selection and small analyzable subset limit inference. Paper reports umami-research funding and software-company author affiliations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A selected subgroup can suggest a mechanism without establishing a population effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Gastric emptying and duodenal motility upon intake of a liquid meal with monosodium glutamate in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24744869/ · DOI 10.1002/phy2.187","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a267b215-75f7-5c25-8859-3216f00d54b4","evidence_kind":"source_excerpt","locator":"Lines 242-248","start_line":242,"end_line":248,"excerpt":"## monosodium-glutamate-mri-responder-analysis\nA selected subgroup can suggest a mechanism without establishing a population effect.\nEight participants had faster emptying with MSG; two slowed. Duodenal wall-motion analysis in four of the eight showed increased motility.\nModel: Same ten-person MRI experiment; subgroup analyses.\nLimitations: Responder selection and small analyzable subset limit inference. Paper reports umami-research funding and software-company author affiliations.\nEvidence access: Primary full text; results and disclosures\nGastric emptying and duodenal motility upon intake of a liquid meal with monosodium glutamate in healthy subjects. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24744869/ · DOI 10.1002/phy2.187","model_system":"Same ten-person MRI experiment; subgroup analyses.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"90a81fe5-8622-52f6-b4db-04899206c2b0","stable_key":"import-561b2b40-5b59-548f-a749-f357f7e2304c","title":"Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"53052c19ee82d400eff7d82ffa3cff74747c7f91a8d173efa3f46eba6bd87cce","revision_id":"fdb64139-32f4-537e-bb0f-f242f2779da8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}