{"id":"cdb36432-dffb-508f-b4e5-4c4dda73b0c5","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ver-oxidized-coq-no-regeneration","predicate":"does-not-detectably-regenerate","statement":"The same solution study detected no reaction of oxidized ubiquinone-10 with tocopheroxyl radicals, distinguishing it from the active reduced ubiquinol-10 form.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"8bef2ef3-f3f0-5b2b-a151-1211dd0492e3","mechanism_event_label":"CoQ10 needed to be in its reduced state for the measured recycling reaction.","subject":{"id":"64f0151b-6c0d-5adf-a6b4-13056bc8dfb3","slug":"ubiquinone-10","display_name":"Ubiquinone-10","entity_type_key":"small_molecule"},"object":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"8bef2ef3-f3f0-5b2b-a151-1211dd0492e3","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:ver-oxidized-coq-no-regeneration-event","event_type":"biochemical_relationship","label":"CoQ10 needed to be in its reduced state for the measured recycling reaction.","description":"The same solution study detected no reaction of oxidized ubiquinone-10 with tocopheroxyl radicals, distinguishing it from the active reduced ubiquinol-10 form.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ec585435-0fdf-5f6f-97d9-6fff230d405e","slug":"alpha-tocopheroxyl-radical","display_name":"Alpha-tocopheroxyl radical","entity_type_key":"chemical_species"},"role":"tested radical","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"64fbe9b3-bf24-5b66-9611-8b78262d6ffc","slug":"reduced-coq10","display_name":"Reduced CoQ10","entity_type_key":"small_molecule"},"role":"active comparator","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"64f0151b-6c0d-5adf-a6b4-13056bc8dfb3","slug":"ubiquinone-10","display_name":"Ubiquinone-10","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Stopped-flow comparison of CoQ10 redox states","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oxidized ubiquinone-10 comparator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A non-detected reaction under these assay conditions is not an assertion that cellular CoQ cannot first be reduced.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Cell-free","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"CoQ10 needed to be in its reduced state for the measured recycling reaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ver-mukai1990] Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution. (1990). https://pubmed.ncbi.nlm.nih.gov/2383582/ DOI: 10.1016/0304-4165(90)90176-w","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Chemical solution","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"070afa0f-8ee9-57d7-88d0-bb65aa3e052a","evidence_kind":"source_excerpt","locator":"Lines 522-534","start_line":522,"end_line":534,"excerpt":"### ver-oxidized-coq-no-regeneration\nThe same solution study detected no reaction of oxidized ubiquinone-10 with tocopheroxyl radicals, distinguishing it from the active reduced ubiquinol-10 form.\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: CoQ10 needed to be in its reduced state for the measured recycling reaction.\norganism: Cell-free\ntissue_or_cell_type: Chemical solution\nexperimental_model: Stopped-flow comparison of CoQ10 redox states\nlimitations: A non-detected reaction under these assay conditions is not an assertion that cellular CoQ cannot first be reduced.\nexposure: Oxidized ubiquinone-10 comparator.\ncross_nutrient: true\nevidence_location: Primary abstract\n[ver-mukai1990] Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution. (1990). https://pubmed.ncbi.nlm.nih.gov/2383582/ DOI: 10.1016/0304-4165(90)90176-w","model_system":"Stopped-flow comparison of CoQ10 redox states","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ver-mukai1990] Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution. (1990). https://pubmed.ncbi.nlm.nih.gov/2383582/ DOI: 10.1016/0304-4165(90)90176-w","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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