{"id":"ccec3907-a8fb-5071-99da-a11c128a7e9a","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-cvd-prevention-null","predicate":"did_not_reduce_major_cardiovascular_event_incidence","statement":"Vitamin C assignment did not reduce major cardiovascular events (HR 0.99; 95% CI 0.89–1.11; P=0.91) over mean eight-year follow-up.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3fe0b914-0033-5ccb-90d3-734319f08612","mechanism_event_label":"A long-term supplement trial did not turn the antioxidant rationale into fewer major cardiovascular events.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"8f08bd23-f5e8-5787-b7b5-d6e1e26ed99c","slug":"major-cardiovascular-event-incidence","display_name":"Major cardiovascular event incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3fe0b914-0033-5ccb-90d3-734319f08612","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-cvd-prevention-null-event","event_type":"observed_intervention","label":"A long-term supplement trial did not turn the antioxidant rationale into fewer major cardiovascular events.","description":"Vitamin C assignment did not reduce major cardiovascular events (HR 0.99; 95% CI 0.89–1.11; P=0.91) over mean eight-year follow-up.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"related_nutrient_in_separate_factorial_assignment","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8f08bd23-f5e8-5787-b7b5-d6e1e26ed99c","slug":"major-cardiovascular-event-incidence","display_name":"Major cardiovascular event incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Clinical outcome boundary for extrapolation from vitamin C/vitamin E redox recycling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Physicians Health Study II: placebo-controlled double-blind factorial trial, 14641 male physicians aged at least 50, mean eight-year follow-up.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Vitamin C 500 mg/day and separately randomized vitamin E 400 IU every other day; 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95% CI 0.89–1.11; P=0.91) over mean eight-year follow-up.\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A long-term supplement trial did not turn the antioxidant rationale into fewer major cardiovascular events.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Physicians Health Study II: placebo-controlled double-blind factorial trial, 14641 male physicians aged at least 50, mean eight-year follow-up.\nlimitations: Older male physicians, not a selected scurvy cohort; separate vitamin E randomization is not proof of molecular synergy or antagonism.\nexposure: Vitamin C 500 mg/day and separately randomized vitamin E 400 IU every other day; clinical CVD endpoints.\ncross_nutrient: Clinical outcome boundary for extrapolation from vitamin C/vitamin E redox recycling.\n[c-sesso2008] Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial (2008). https://pubmed.ncbi.nlm.nih.gov/18997197/ DOI: 10.1001/jama.2008.600","model_system":"Physicians Health Study II: placebo-controlled double-blind factorial trial, 14641 male physicians aged at least 50, mean eight-year follow-up.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-sesso2008] Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial (2008). https://pubmed.ncbi.nlm.nih.gov/18997197/ DOI: 10.1001/jama.2008.600","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}