{"id":"cce7ee91-42e9-5d4f-88ff-f2468b1069b0","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-germfree-energy","predicate":"modulates","statement":"Germ-free mouse colonocytes had reduced NADH/NAD+, oxidative phosphorylation and ATP; adding butyrate rescued mitochondrial respiration.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5dd629da-8a4b-5ca3-8c99-c3e4f1ac8543","mechanism_event_label":"Removing the microbiota deprived colon cells of an important fuel; adding it back restored respiration.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"fe825a6a-9106-5a28-a1ed-3ac0d56bd2ae","slug":"mouse-colonocyte-energy-state","display_name":"Mouse colonocyte mitochondrial respiration and energy state","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5dd629da-8a4b-5ca3-8c99-c3e4f1ac8543","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-germfree-energy-event","event_type":"observed_relationship","label":"Removing the microbiota deprived colon cells of an important fuel; 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evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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