{"id":"cce1652f-2d05-5ed4-9773-5cdf1d815b6b","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-neuro-normal-blood-counts","predicate":"deficiency_occurred_with_normal_blood_counts","statement":"Of 141 neurologic B12-deficiency patients, 34 had normal hematocrit, 25 normal mean cell volume, and 19 both; 40 lacked at least one of these two abnormalities.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f69c742e-8ac8-58f3-91ed-56752b88cb11","mechanism_event_label":"Normal red-cell size or hematocrit did not exclude the neurologic presentation.","subject":{"id":"b6d9b937-895d-5e0a-8cc5-0454a0b7d373","slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"},"object":{"id":"f6446e4d-cd6a-5d7e-889e-b2eb19e27940","slug":"b12-neuropsychiatric-impairment","display_name":"B12-associated neuropsychiatric impairment","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f69c742e-8ac8-58f3-91ed-56752b88cb11","stable_key":"7fc92b9e-9cbf-556e-8719-6b5244625250:b12-neuro-normal-blood-counts-event","event_type":"observed_intervention","label":"Normal red-cell size or hematocrit did not exclude the neurologic presentation.","description":"Of 141 neurologic B12-deficiency patients, 34 had normal hematocrit, 25 normal mean cell volume, and 19 both; 40 lacked at least one of these two abnormalities.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"26a853d3-5b09-56f4-a814-03f922687d0e","slug":"hematocrit","display_name":"Hematocrit","entity_type_key":"cellular_process"},"role":"measured_marker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aa4f9545-abea-55c8-ab10-6ec530caa23f","slug":"erythrocyte-mean-cell-volume","display_name":"Erythrocyte mean cell volume","entity_type_key":"cellular_process"},"role":"measured_marker","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b6d9b937-895d-5e0a-8cc5-0454a0b7d373","slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f6446e4d-cd6a-5d7e-889e-b2eb19e27940","slug":"b12-neuropsychiatric-impairment","display_name":"B12-associated neuropsychiatric impairment","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Clinical series: 141 consecutive patients with neuropsychiatric abnormalities attributed to cobalamin deficiency; 40 lacked anemia or macrocytosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Clinical evaluation and cobalamin replacement; observational response series.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The reported 28% is not the percentage with both tests normal. Selected patients do not estimate population prevalence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b12","display_name":"Vitamin B12 (cobalamins)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Normal red-cell size or hematocrit did not exclude the neurologic presentation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b12-lindenbaum1988] Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis (1988). https://pubmed.ncbi.nlm.nih.gov/3374544/ DOI: 10.1056/nejm198806303182604","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"00c72100-c011-5c43-932c-e5691c31ba76","evidence_kind":"source_excerpt","locator":"Lines 1426-1436","start_line":1426,"end_line":1436,"excerpt":"### b12-neuro-normal-blood-counts\nOf 141 neurologic B12-deficiency patients, 34 had normal hematocrit, 25 normal mean cell volume, and 19 both; 40 lacked at least one of these two abnormalities.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin B12 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Normal red-cell size or hematocrit did not exclude the neurologic presentation.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Clinical series: 141 consecutive patients with neuropsychiatric abnormalities attributed to cobalamin deficiency; 40 lacked anemia or macrocytosis.\nlimitations: The reported 28% is not the percentage with both tests normal. Selected patients do not estimate population prevalence.\nexposure: Clinical evaluation and cobalamin replacement; observational response series.\n[b12-lindenbaum1988] Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis (1988). https://pubmed.ncbi.nlm.nih.gov/3374544/ DOI: 10.1056/nejm198806303182604","model_system":"Clinical series: 141 consecutive patients with neuropsychiatric abnormalities attributed to cobalamin deficiency; 40 lacked anemia or macrocytosis.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b12-lindenbaum1988] Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis (1988). https://pubmed.ncbi.nlm.nih.gov/3374544/ DOI: 10.1056/nejm198806303182604","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73145023-2982-5848-aff2-8d8875d6b9c5","stable_key":"import-7fc92b9e-9cbf-556e-8719-6b5244625250","title":"Vitamin B12: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ad5b3a51d36e856aa7fdfd1cc23f690b094689bad87d28e1a621a54675a01c92","revision_id":"118bd616-0c13-549f-bfeb-bc439715b89c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}