{"id":"ccdeb0b4-274e-5d29-ac9a-bb0f5dae9c7a","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-mcp-collagen-null","predicate":"did_not_significantly_change","statement":"MCP did not produce the proposed improvement in collagen turnover markers; the borderline PIIINP between-group difference (p=0.05) was driven mainly by an increase in the MCP group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5bfe34ff-a57c-59ff-8b51-ed2f808a0e4b","mechanism_event_label":"The human trial did not confirm the proposed antifibrotic marker benefit.","subject":{"id":"cd34197d-e78f-5adb-80a9-eb423fb115c4","slug":"modified-citrus-pectin","display_name":"Modified citrus pectin, product-specific","entity_type_key":"chemical_species"},"object":{"id":"671153c1-63d4-5e32-be54-7466ac014191","slug":"human-collagen-turnover-markers","display_name":"Human circulating collagen turnover markers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5bfe34ff-a57c-59ff-8b51-ed2f808a0e4b","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-mcp-collagen-null-event","event_type":"observed_intervention","label":"The human trial did not confirm the proposed antifibrotic marker benefit.","description":"MCP did not produce the proposed improvement in collagen turnover markers; the borderline PIIINP between-group difference (p=0.05) was driven mainly by an increase in the MCP group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"cd34197d-e78f-5adb-80a9-eb423fb115c4","slug":"modified-citrus-pectin","display_name":"Modified citrus pectin, product-specific","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"671153c1-63d4-5e32-be54-7466ac014191","slug":"human-collagen-turnover-markers","display_name":"Human circulating collagen turnover markers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/33532663.fulltext.txt\", \"locator\": \"Primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9600257cc318b4b6bdb0c2d95c4b42f8644220c06bb0581dc604ca4e7d7ba051\", \"start_char\": 14495, \"end_char\": 19456, \"text_sha256\": \"7914ef3745e7ff82580f8ed02f013628d44c7461d6ce4dbc254b273561c8a732\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized placebo-controlled proof-of-concept trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"68 randomized participants with hypertension and elevated galectin-3; Pectasol-C 4.8 g three times/day for six months; 52 had complete biomarker data","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Target inhibition was not established by dosing alone. Surrogate endpoints and incomplete follow-up; no demonstrated heart-failure treatment benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The human trial did not confirm the proposed antifibrotic marker benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p33532663] Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension. (2021). https://pubmed.ncbi.nlm.nih.gov/33532663/ DOI: 10.1016/j.jacbts.2020.10.006","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood collagen markers, cardiac and vascular assessments","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"95edb3f1-f696-5cf3-bffd-e5609ad8330f","evidence_kind":"source_excerpt","locator":"Lines 1049-1060","start_line":1049,"end_line":1060,"excerpt":"### pectin-mcp-collagen-null\nMCP did not produce the proposed improvement in collagen turnover markers; the borderline PIIINP between-group difference (p=0.05) was driven mainly by an increase in the MCP group.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The human trial did not confirm the proposed antifibrotic marker benefit.\norganism: Homo sapiens\ntissue_or_cell_type: Blood collagen markers, cardiac and vascular assessments\nexperimental_model: Double-blind randomized placebo-controlled proof-of-concept trial\nlimitations: Target inhibition was not established by dosing alone. Surrogate endpoints and incomplete follow-up; no demonstrated heart-failure treatment benefit.\nexposure: 68 randomized participants with hypertension and elevated galectin-3; Pectasol-C 4.8 g three times/day for six months; 52 had complete biomarker data\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/33532663.fulltext.txt\", \"locator\": \"Primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9600257cc318b4b6bdb0c2d95c4b42f8644220c06bb0581dc604ca4e7d7ba051\", \"start_char\": 14495, \"end_char\": 19456, \"text_sha256\": \"7914ef3745e7ff82580f8ed02f013628d44c7461d6ce4dbc254b273561c8a732\"}\n[pectin-p33532663] Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension. 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