{"id":"cca6d1f4-b911-5765-9c5b-2cdc2a028885","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-borrelidin-competition","predicate":"competes_at","statement":"Borrelidin-class inhibitor toxicity was linked to competition with threonine at TARS, provoking amino-acid-starvation responses and apoptosis in the studied systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"190bd6a1-513c-5b54-981c-7645cc1d1778","mechanism_event_label":"Blocking amino-acid processing can mimic inadequate supply inside a cell.","subject":{"id":"7d40cf20-e80b-56a4-9d70-5b215700fa00","slug":"borrelidin","display_name":"Borrelidin","entity_type_key":"drug"},"object":{"id":"42b7656b-93a3-5348-a7cf-775072512653","slug":"tars1","display_name":"Human cytosolic threonyl-tRNA synthetase / TARS1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"190bd6a1-513c-5b54-981c-7645cc1d1778","stable_key":"97957230-601f-5dec-8524-0812be8fadbf:l-threonine-borrelidin-competition-event","event_type":"observed_relationship","label":"Blocking amino-acid processing can mimic inadequate supply inside a cell.","description":"Borrelidin-class inhibitor toxicity was linked to competition with threonine at TARS, provoking amino-acid-starvation responses and apoptosis in the studied systems.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7d40cf20-e80b-56a4-9d70-5b215700fa00","slug":"borrelidin","display_name":"Borrelidin","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"42b7656b-93a3-5348-a7cf-775072512653","slug":"tars1","display_name":"Human cytosolic threonyl-tRNA synthetase / TARS1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fcef4dc2-a7b6-5812-bc33-c8af3d83f4d0","slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Enzyme biochemistry, structures, cellular assays and zebrafish work.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Anti-angiogenic action could be separated from toxicity with selected derivatives; these are experimental agents, not routine nutrient interactions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Threonine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-threonine","display_name":"L-Threonine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Blocking amino-acid processing can mimic inadequate supply inside a cell.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26271225/ · DOI 10.1038/srep13160","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f7c39a60-0c07-5f48-9b77-9ab084d9b8b3","evidence_kind":"source_excerpt","locator":"Lines 394-400","start_line":394,"end_line":400,"excerpt":"## l-threonine-borrelidin-competition\nBlocking amino-acid processing can mimic inadequate supply inside a cell.\nBorrelidin-class inhibitor toxicity was linked to competition with threonine at TARS, provoking amino-acid-starvation responses and apoptosis in the studied systems.\nModel: Enzyme biochemistry, structures, cellular assays and zebrafish work.\nLimitations: Anti-angiogenic action could be separated from toxicity with selected derivatives; these are experimental agents, not routine nutrient interactions.\nEvidence access: Primary abstract\nAminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26271225/ · DOI 10.1038/srep13160","model_system":"Enzyme biochemistry, structures, cellular assays and zebrafish work.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"35396730-235a-537e-8a05-c6ef2960c509","stable_key":"import-97957230-601f-5dec-8524-0812be8fadbf","title":"L-Threonine: translation, intestinal barrier, metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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