{"id":"cc88af6c-f524-5a89-85c9-c704104bc29a","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-trp14-cystine-reduction","predicate":"reduces_cystine_to","statement":"TXNDC17 knockout in human HEK293 cells markedly reduced intracellular cystine reduction; wild-type TRP14 re-expression restored activity whereas its active-site mutant did not.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"43fe0a23-f24b-503f-93ed-5c0b578e9965","mechanism_event_label":"Importing oxidized cysteine is not enough: the cell must reduce it to use it.","subject":{"id":"8e8b774c-00bd-5f89-b450-e0e5c4a7fb77","slug":"txndc17","display_name":"Human thioredoxin-related protein 14 / TXNDC17","entity_type_key":"protein"},"object":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"43fe0a23-f24b-503f-93ed-5c0b578e9965","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-trp14-cystine-reduction-event","event_type":"observed_relationship","label":"Importing oxidized cysteine is not enough: the cell must reduce it to use it.","description":"TXNDC17 knockout in human HEK293 cells markedly reduced intracellular cystine reduction; 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