{"id":"cc61bc93-3450-57ca-afbb-41f6c1810901","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-acetyl-carbon","predicate":"supplies","statement":"Isotope-labeled acetylcarnitine supplied acetyl-CoA and fatty-acid carbon in glucose-limited human U87MG glioma cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5f194051-b2ed-5478-bf5c-e939d745cb3b","mechanism_event_label":"The acetylated form can deliver carbon for cellular synthesis.","subject":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"object":{"id":"cf898787-c987-53c5-a7c8-d5ae2cf75219","slug":"human-u87mg-acetyl-coa-labeling","display_name":"Human U87MG acetyl-CoA labeling from acetylcarnitine","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5f194051-b2ed-5478-bf5c-e939d745cb3b","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-acetyl-carbon-event","event_type":"observed_relationship","label":"The acetylated form can deliver carbon for cellular synthesis.","description":"Isotope-labeled acetylcarnitine supplied acetyl-CoA and fatty-acid carbon in glucose-limited human U87MG glioma cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ce394a9-6ec6-56dd-866f-37d85c0556e4","slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cf898787-c987-53c5-a7c8-d5ae2cf75219","slug":"human-u87mg-acetyl-coa-labeling","display_name":"Human U87MG acetyl-CoA labeling from acetylcarnitine","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b7ed6e4c-e560-5cee-b68f-895f21862e6f","slug":"acetyl-coa","display_name":"Acetyl-CoA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4527896a-05c1-5889-be74-b4b42f154402","slug":"human-u87mg-fatty-acid-labeling","display_name":"Human U87MG fatty-acid labeling from acetylcarnitine","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human U87MG culture, isotope tracing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not show that oral acetylcarnitine causes or treats cancer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Carnitine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The acetylated form can deliver carbon for cellular synthesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Carnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36587768/ · DOI 10.1016/j.jbc.2022.102848","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"83181a62-eeab-5d27-8ebb-d69c62a11fdc","evidence_kind":"source_excerpt","locator":"Lines 210-216","start_line":210,"end_line":216,"excerpt":"## l-carnitine-acetyl-carbon\nThe acetylated form can deliver carbon for cellular synthesis.\nIsotope-labeled acetylcarnitine supplied acetyl-CoA and fatty-acid carbon in glucose-limited human U87MG glioma cells.\nModel: Human U87MG culture, isotope tracing.\nLimitations: Does not show that oral acetylcarnitine causes or treats cancer.\nEvidence access: Primary abstract\nCarnitine octanoyltransferase is important for the assimilation of exogenous acetyl-L-carnitine into acetyl-CoA in mammalian cells. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36587768/ · DOI 10.1016/j.jbc.2022.102848","model_system":"Human U87MG culture, isotope tracing.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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