{"id":"cc5430b7-5034-546e-b30a-b4ce477d0889","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-vitamin-d3-null","predicate":"does_not_increase","statement":"Correcting vitamin D deficiency with vitamin D3 did not increase the measured strontium-ranelate absorption in the study of postmenopausal women with low bone mass.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"22d2844b-8de8-51ff-ad5c-c1e33b3e758f","mechanism_event_label":"Improving vitamin D status did not automatically improve strontium absorption.","subject":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"object":{"id":"31bf058b-2152-5e0d-8191-acfbee9199c9","slug":"human-intestinal-strontium-absorption","display_name":"Human intestinal strontium absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"22d2844b-8de8-51ff-ad5c-c1e33b3e758f","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-vitamin-d3-null-event","event_type":"observed_relationship","label":"Improving vitamin D status did not automatically improve strontium absorption.","description":"Correcting vitamin D deficiency with vitamin D3 did not increase the measured strontium-ranelate absorption in the study of postmenopausal women with low bone mass.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"31bf058b-2152-5e0d-8191-acfbee9199c9","slug":"human-intestinal-strontium-absorption","display_name":"Human intestinal strontium absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a319eca8-b0ed-5a8c-8659-e7f106bed73a","slug":"strontium-ranelate","display_name":"Strontium ranelate","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"25 women below 50 nmol/L 25(OH)D and 25 above 75 nmol/L; deficient group retested after repletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mild deficiency, oral overload test and D3 intervention differ from the four-patient calcitriol experiment; not a scientific contradiction or evidence against treating vitamin D deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Improving vitamin D status did not automatically improve strontium absorption.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Vitamin D supplementation and strontium ranelate absorption in postmenopausal women with low bone mass. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24394724/ · DOI 10.1530/EJE-13-0899","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"09c8c294-c21c-57c7-b864-32c01a8e039b","evidence_kind":"source_excerpt","locator":"Lines 62-68","start_line":62,"end_line":68,"excerpt":"## strontium-vitamin-d3-null\nImproving vitamin D status did not automatically improve strontium absorption.\nCorrecting vitamin D deficiency with vitamin D3 did not increase the measured strontium-ranelate absorption in the study of postmenopausal women with low bone mass.\nModel: 25 women below 50 nmol/L 25(OH)D and 25 above 75 nmol/L; deficient group retested after repletion.\nLimitations: Mild deficiency, oral overload test and D3 intervention differ from the four-patient calcitriol experiment; not a scientific contradiction or evidence against treating vitamin D deficiency.\nEvidence access: Primary abstract\nVitamin D supplementation and strontium ranelate absorption in postmenopausal women with low bone mass. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24394724/ · DOI 10.1530/EJE-13-0899","model_system":"25 women below 50 nmol/L 25(OH)D and 25 above 75 nmol/L; deficient group retested after repletion.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"43ef0fe7-eb6c-5346-8381-f7694733b4dc","stable_key":"import-1ff3a29f-ef80-5bff-9300-30b98c60b90d","title":"Strontium: calcium interactions, cellular mechanisms and mineralization (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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