{"id":"cc4bfff8-a19a-5884-bf92-790f0f944e60","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-hcar2-restoration","predicate":"restoration_enables","statement":"Restoring GPR109A expression in human colon cancer cells enabled apoptosis in the presence of butyrate or nicotinate; the receptor-mediated response did not require histone deacetylation inhibition.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a208eaf1-3af7-5457-ba1d-aa820d36f17e","mechanism_event_label":"Restoring the receptor enabled a response distinct from the HDAC pathway.","subject":{"id":"c31b5501-5abf-57bb-8324-15923ed678cf","slug":"hcar2","display_name":"Human hydroxycarboxylic acid receptor 2 / HCAR2","entity_type_key":"protein"},"object":{"id":"1e0ebdfb-cd1d-5ace-aaf9-baefd0cb1da9","slug":"human-hcar2-restored-cancer-apoptosis","display_name":"Apoptosis in human colon cancer cells with restored HCAR2","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a208eaf1-3af7-5457-ba1d-aa820d36f17e","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-hcar2-restoration-event","event_type":"observed_relationship","label":"Restoring the receptor enabled a response distinct from the HDAC pathway.","description":"Restoring GPR109A expression in human colon cancer cells enabled apoptosis in the presence of butyrate or nicotinate; 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