{"id":"cbd11c41-0a71-57a9-96c3-14f2eb495e6d","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-mk7-cad-carboxylation","predicate":"reduces","statement":"With calcium and D3 in both groups, MK-7 reduced ucOC by about 65% after one year.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d7dadb7d-d447-5bc0-980b-99c0a4fc2c29","mechanism_event_label":"Adding K2 changed the protein marker even with calcium and vitamin D already supplied.","subject":{"id":"a3ff2a7b-69f3-5098-8fac-fb8d7668397b","slug":"menaquinone-7","display_name":"Menaquinone-7 / MK-7","entity_type_key":"small_molecule"},"object":{"id":"11fdba27-fa4e-5ac5-bf7e-7c22b6c72478","slug":"undercarboxylated-osteocalcin","display_name":"Undercarboxylated osteocalcin","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"d7dadb7d-d447-5bc0-980b-99c0a4fc2c29","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-mk7-cad-carboxylation-event","event_type":"observed_intervention","label":"Adding K2 changed the protein marker even with calcium and vitamin D already supplied.","description":"With calcium and D3 in both groups, MK-7 reduced ucOC by about 65% after one year.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"shared_background","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"shared_background","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a3ff2a7b-69f3-5098-8fac-fb8d7668397b","slug":"menaquinone-7","display_name":"Menaquinone-7 / MK-7","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"11fdba27-fa4e-5ac5-bf7e-7c22b6c72478","slug":"undercarboxylated-osteocalcin","display_name":"Undercarboxylated osteocalcin","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/k2-research/33030563.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"008ef1b176a3f718d923eea696a7a97b09d64e3079e57c997beaf485153ca138\", \"start_char\": 0, \"end_char\": 2370, \"text_sha256\": \"008ef1b176a3f718d923eea696a7a97b09d64e3079e57c997beaf485153ca138\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three-year double-blind randomized add-on trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"MK-7 375 micrograms/day versus placebo; both groups D3 38 micrograms/day and calcium 800 mg/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different population, dose and background supplementation from the 180-microgram trial; the one-year and three-year reports are not independent cohorts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"142 postmenopausal women with osteopenia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding K2 changed the protein marker even with calcium and vitamin D already supplied.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k2-p33030563] The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial. (2021). https://pubmed.ncbi.nlm.nih.gov/33030563/ DOI: 10.1007/s00198-020-05638-z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Osteocalcin, DXA and bone microarchitecture","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8f403b7d-901b-5b83-aff2-e87bb1a4eb5d","evidence_kind":"source_excerpt","locator":"Lines 1085-1096","start_line":1085,"end_line":1096,"excerpt":"### k2-mk7-cad-carboxylation\nWith calcium and D3 in both groups, MK-7 reduced ucOC by about 65% after one year.\nCondition category: normal\nnutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Adding K2 changed the protein marker even with calcium and vitamin D already supplied.\norganism: 142 postmenopausal women with osteopenia\ntissue_or_cell_type: Osteocalcin, DXA and bone microarchitecture\nexperimental_model: Three-year double-blind randomized add-on trial\nlimitations: Different population, dose and background supplementation from the 180-microgram trial; the one-year and three-year reports are not independent cohorts.\nexposure: MK-7 375 micrograms/day versus placebo; both groups D3 38 micrograms/day and calcium 800 mg/day\nevidence_span: {\"source_cache\": \"artifacts/k2-research/33030563.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"008ef1b176a3f718d923eea696a7a97b09d64e3079e57c997beaf485153ca138\", \"start_char\": 0, \"end_char\": 2370, \"text_sha256\": \"008ef1b176a3f718d923eea696a7a97b09d64e3079e57c997beaf485153ca138\"}\n[k2-p33030563] The effect of vitamin MK-7 on bone mineral density and microarchitecture in postmenopausal women with osteopenia, a 3-year randomized, placebo-controlled clinical trial. 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