{"id":"cb927788-7fda-55a2-be39-89805bcae0d0","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-human-metr-saar","predicate":"differs_from_combined_restriction_in","statement":"In twenty adults, four-week methionine-only restriction changed fewer metabolic markers than combined methionine/cysteine restriction; both increased FGF21 in the reported comparisons.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"88827887-482b-5b07-966f-cd036a7504f6","mechanism_event_label":"Restricting one sulfur amino acid is not the same intervention as restricting both.","subject":{"id":"2fa490e6-50cc-5a22-b1ea-af5e128666e4","slug":"experimental-methionine-restriction","display_name":"Experimentally methionine-restricted diet","entity_type_key":"cellular_process"},"object":{"id":"27cf5707-cfc4-572e-b6c5-5303338a0b7c","slug":"human-methionine-versus-sulfur-restriction","display_name":"Human metabolic responses to methionine-only versus total sulfur restriction","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"88827887-482b-5b07-966f-cd036a7504f6","stable_key":"41a89233-da9a-5b7b-9c18-e19bbadcfe2d:methionine-human-metr-saar-event","event_type":"observed_relationship","label":"Restricting one sulfur amino acid is not the same intervention as restricting both.","description":"In twenty adults, four-week methionine-only restriction changed fewer metabolic markers than combined methionine/cysteine restriction; 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sequential control, moderate and greater restriction periods separated by washouts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small short-term study with fixed diet-period ordering; no lifespan or cancer outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Methionine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Restricting one sulfur amino acid is not the same intervention as restricting both.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36806866/ · DOI 10.1007/s12603-023-1883-3","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"df2115fb-9c8a-5ad2-9251-4205bdba40a7","evidence_kind":"source_excerpt","locator":"Lines 396-402","start_line":396,"end_line":402,"excerpt":"## methionine-human-metr-saar\nRestricting one sulfur amino acid is not the same intervention as restricting both.\nIn twenty adults, four-week methionine-only restriction changed fewer metabolic markers than combined methionine/cysteine restriction; both increased FGF21 in the reported comparisons.\nModel: Controlled feeding; sequential control, moderate and greater restriction periods separated by washouts.\nLimitations: Small short-term study with fixed diet-period ordering; no lifespan or cancer outcomes.\nEvidence access: Primary abstract\nDietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults. · 2023 · https://pubmed.ncbi.nlm.nih.gov/36806866/ · DOI 10.1007/s12603-023-1883-3","model_system":"Controlled feeding; sequential control, moderate and greater restriction periods separated by washouts.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d969b004-ccc2-5bb4-9109-8ac649137ad1","stable_key":"import-41a89233-da9a-5b7b-9c18-e19bbadcfe2d","title":"L-Methionine: transport, methylation, sulfur metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; 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