{"id":"cb6d4efd-c3d7-5720-9b49-68f2e2389ed9","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-wham-retinal-repletion-failure","predicate":"fails_to_normalize","statement":"High-lutein feeding left WHAM retinal lutein near 6% of controls despite increases in plasma, liver and heart.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3b66dd62-2c10-5082-8544-6d9ddc880505","mechanism_event_label":"More intake did not repair retinal delivery in this model.","subject":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"object":{"id":"f2bfc8e0-8200-5650-a88d-f9258fe973c4","slug":"chicken-retinal-lutein","display_name":"Chicken retinal lutein content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3b66dd62-2c10-5082-8544-6d9ddc880505","stable_key":"cfa4bd86-d88d-555a-975c-68877bf00e0f:lutein-wham-retinal-repletion-failure-event","event_type":"biochemical_relationship","label":"More intake did not repair retinal delivery in this model.","description":"High-lutein feeding left WHAM retinal lutein near 6% of controls despite increases in plasma, liver and heart.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5dd84367-3f8e-5a3f-b952-a96174ea51fa","slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2bfc8e0-8200-5650-a88d-f9258fe973c4","slug":"chicken-retinal-lutein","display_name":"Chicken retinal lutein content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lutein-research/17724211.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4\", \"start_char\": 0, \"end_char\": 1727, \"text_sha256\": \"7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"High-lutein feeding in WHAM versus control chicks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"High-lutein or control diet from hatching for 28 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal transport failure; raising human HDL cholesterol is not established as a way to improve retinal lutein.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lutein research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lutein","display_name":"Lutein","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Chicken","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More intake did not repair retinal delivery in this model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lutein-p17724211] The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporter. (2007). https://pubmed.ncbi.nlm.nih.gov/17724211/ DOI: 10.1167/iovs.06-1275","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma, retina, liver and heart","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"3c99d9f4-57b4-5dd3-bba3-b9943bb7a741","evidence_kind":"source_excerpt","locator":"Lines 411-422","start_line":411,"end_line":422,"excerpt":"### lutein-wham-retinal-repletion-failure\nHigh-lutein feeding left WHAM retinal lutein near 6% of controls despite increases in plasma, liver and heart.\nCondition category: machinery_impairment\nnutrient_topic: Lutein research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: More intake did not repair retinal delivery in this model.\norganism: Chicken\ntissue_or_cell_type: Plasma, retina, liver and heart\nexperimental_model: High-lutein feeding in WHAM versus control chicks\nlimitations: Animal transport failure; raising human HDL cholesterol is not established as a way to improve retinal lutein.\nexposure: High-lutein or control diet from hatching for 28 days\nevidence_span: {\"source_cache\": \"artifacts/lutein-research/17724211.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4\", \"start_char\": 0, \"end_char\": 1727, \"text_sha256\": \"7d7044cc9e41a7d859e5d5d75fc3fb7381d11fa635fa7232bf9dc97b83bd4cf4\"}\n[lutein-p17724211] The prime role of HDL to transport lutein into the retina: evidence from HDL-deficient WHAM chicks having a mutant ABCA1 transporter. 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