{"id":"cb2624e2-903c-5228-94c9-1228fd7cbabb","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-human-trpc3","predicate":"reduces","statement":"Taurine treatment reduced agonist-induced vascular reactivity through inhibition of TRPC3-mediated calcium influx in human mesenteric artery experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"559fecf6-ea53-54a5-9cd0-8fd2552c7122","mechanism_event_label":"The mechanistic experiments implicated a calcium entry channel.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"a82c2ad9-5332-5d9b-a01b-1e4e6fc51eb4","slug":"human-mesenteric-trpc3-calcium","display_name":"TRPC3-mediated calcium influx in human mesenteric arteries","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"559fecf6-ea53-54a5-9cd0-8fd2552c7122","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-human-trpc3-event","event_type":"observed_relationship","label":"The mechanistic experiments implicated a calcium entry channel.","description":"Taurine treatment reduced agonist-induced vascular reactivity through inhibition of TRPC3-mediated calcium influx in human mesenteric artery experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a82c2ad9-5332-5d9b-a01b-1e4e6fc51eb4","slug":"human-mesenteric-trpc3-calcium","display_name":"TRPC3-mediated calcium influx in human mesenteric arteries","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"deec0b73-06cc-5826-b218-ef12231048ba","slug":"trpc3","display_name":"Human TRPC3 calcium-permeable channel","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"70cc3ced-8adc-5e76-9750-e1415683455b","slug":"hydrogen-sulfide","display_name":"Hydrogen sulfide / H2S","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human artery preparations in the translational blood-pressure study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not infer that oral taurine directly binds TRPC3; the signaling pathway and clinical mediation are distinct.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The mechanistic experiments implicated a calcium entry channel.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26781281/ · DOI 10.1161/HYPERTENSIONAHA.115.06624","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1e5bef5a-b538-5308-b1c9-2091c8d29b0d","evidence_kind":"source_excerpt","locator":"Lines 497-503","start_line":497,"end_line":503,"excerpt":"## taurine-human-trpc3\nThe mechanistic experiments implicated a calcium entry channel.\nTaurine treatment reduced agonist-induced vascular reactivity through inhibition of TRPC3-mediated calcium influx in human mesenteric artery experiments.\nModel: Human artery preparations in the translational blood-pressure study.\nLimitations: Do not infer that oral taurine directly binds TRPC3; the signaling pathway and clinical mediation are distinct.\nEvidence access: Primary abstract\nTaurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. · 2016 · https://pubmed.ncbi.nlm.nih.gov/26781281/ · DOI 10.1161/HYPERTENSIONAHA.115.06624","model_system":"Human artery preparations in the translational blood-pressure study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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