{"id":"caec2333-3529-5f5e-b905-b317c7927306","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-got1-reversal","predicate":"synthesizes_under_etc_inhibition","statement":"Under electron-transport-chain inhibition, human GOT1 supported cytosolic aspartate synthesis rather than its usual aspartate-consuming shuttle direction.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b6682f6a-1d8f-52b7-9591-9566ff8791a3","mechanism_event_label":"A reversible enzyme can run in a different direction when the cell’s redox state changes.","subject":{"id":"4c4eee53-67f4-5c46-aa5f-ba2bcaf3424d","slug":"got1","display_name":"Human cytosolic aspartate aminotransferase / GOT1","entity_type_key":"protein"},"object":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"b6682f6a-1d8f-52b7-9591-9566ff8791a3","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-got1-reversal-event","event_type":"observed_relationship","label":"A reversible enzyme can run in a different direction when the cell’s redox state changes.","description":"Under electron-transport-chain inhibition, human GOT1 supported cytosolic aspartate synthesis rather than its usual aspartate-consuming shuttle direction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4c4eee53-67f4-5c46-aa5f-ba2bcaf3424d","slug":"got1","display_name":"Human cytosolic aspartate aminotransferase / GOT1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"32119d9f-54be-5e6d-98da-1621b0e2421d","slug":"oxaloacetate","display_name":"Oxaloacetate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"628ddc2d-e4d9-59c7-ae76-0c0cab80a6b1","slug":"2-oxoglutarate","display_name":"2-Oxoglutarate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":6,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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