{"id":"cac8424d-2edc-5912-b5ec-a71409a5da3f","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-scurvy-wound-rate-boundary","predicate":"depletion_did_not_abnormally_change_tested_wound_rate","statement":"Despite the clinical scurvy signs, the report found no abnormality in the measured wound-healing rate, blood counts or coagulation tests.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"01b2e66f-c790-5557-b290-ae54070395c2","mechanism_event_label":"Not every commonly expected scurvy endpoint changed in this particular experiment.","subject":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"object":{"id":"cbcab9c0-a8c3-5b79-96c2-78dd65c94543","slug":"experimental-wound-healing-rate","display_name":"Experimental wound healing rate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"01b2e66f-c790-5557-b290-ae54070395c2","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-scurvy-wound-rate-boundary-event","event_type":"observed_intervention","label":"Not every commonly expected scurvy endpoint changed in this particular experiment.","description":"Despite the clinical scurvy signs, the report found no abnormality in the measured wound-healing rate, blood counts or coagulation tests.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da1a7137-08f2-5a36-8bb6-377fbd32e327","slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cbcab9c0-a8c3-5b79-96c2-78dd65c94543","slug":"experimental-wound-healing-rate","display_name":"Experimental wound healing rate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Diet devoid of vitamin C but adequate in other essential nutrients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Wound closure rate is not scar breaking strength; the inspected summary does not establish preserved collagen quality or contradict all wound-healing studies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Not every commonly expected scurvy endpoint changed in this particular experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-hodges1969] Experimental scurvy in man (1969). https://pubmed.ncbi.nlm.nih.gov/4977512/ DOI: 10.1093/ajcn/22.5.535","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"395de5a9-fd19-5f09-babc-e4f579b4ddf6","evidence_kind":"source_excerpt","locator":"Lines 1517-1527","start_line":1517,"end_line":1527,"excerpt":"### c-scurvy-wound-rate-boundary\nDespite the clinical scurvy signs, the report found no abnormality in the measured wound-healing rate, blood counts or coagulation tests.\nCondition category: nutrient_deficiency\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Not every commonly expected scurvy endpoint changed in this particular experiment.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.\nlimitations: Wound closure rate is not scar breaking strength; the inspected summary does not establish preserved collagen quality or contradict all wound-healing studies.\nexposure: Diet devoid of vitamin C but adequate in other essential nutrients.\n[c-hodges1969] Experimental scurvy in man (1969). https://pubmed.ncbi.nlm.nih.gov/4977512/ DOI: 10.1093/ajcn/22.5.535","model_system":"Historical metabolic-ward study: six apparently healthy male prisoners enrolled, four completed vitamin C deprivation and developed scurvy.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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