{"id":"ca6747cf-0718-5af3-846f-45a7753c0448","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-il6-hepcidin","predicate":"induces","statement":"IL-6 induced hepcidin in the tested human liver-cell, mouse and volunteer systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"145405c7-35b2-5a54-865e-90cdc86f7a8e","mechanism_event_label":"Inflammation can turn up the hormone that restricts iron release.","subject":{"id":"ef8f8807-395d-5dc6-9693-70e90f41b268","slug":"il6","display_name":"IL6","entity_type_key":"cytokine"},"object":{"id":"35dd1617-1218-5059-9c9f-cf7562963f67","slug":"hepcidin-expression","display_name":"Hepcidin expression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"145405c7-35b2-5a54-865e-90cdc86f7a8e","stable_key":"e13b03e1-a614-543a-ac1b-97df18cfe30d:iron-il6-hepcidin-event","event_type":"biochemical_relationship","label":"Inflammation can turn up the hormone that restricts iron release.","description":"IL-6 induced hepcidin in the tested human liver-cell, mouse and volunteer systems.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6d4be6b8-eba9-5d6b-93f9-4642b87f7b6f","slug":"hamp","display_name":"Hepcidin","entity_type_key":"protein"},"role":"induced_hormone","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7adb0f05-bfcc-5951-ad82-46fba12bb073","slug":"mouse-il6","display_name":"Mouse interleukin-6 / Il6","entity_type_key":"protein"},"role":"mouse_ortholog","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ef8f8807-395d-5dc6-9693-70e90f41b268","slug":"il6","display_name":"IL6","entity_type_key":"cytokine"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"35dd1617-1218-5059-9c9f-cf7562963f67","slug":"hepcidin-expression","display_name":"Hepcidin expression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iron-research/15124018.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f2ed307ef57c255917685bb7bfb1f02f3a6481c732cc2ee41ad1f338e2a2a830\", \"start_char\": 0, \"end_char\": 578, \"text_sha256\": \"f2ed307ef57c255917685bb7bfb1f02f3a6481c732cc2ee41ad1f338e2a2a830\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human liver-cell, mouse and human-volunteer inflammation experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"IL-6 and inflammatory stimulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"IL-6 dependence applies to the tested inflammatory models, not every possible inflammatory iron pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Humans and mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Inflammation can turn up the hormone that restricts iron release.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iron-p15124018] IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. (2004). https://pubmed.ncbi.nlm.nih.gov/15124018/ DOI: 10.1172/jci20945","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver and circulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b4552847-0774-5d3d-9f48-1d1cc578d250","evidence_kind":"source_excerpt","locator":"Lines 875-886","start_line":875,"end_line":886,"excerpt":"### iron-il6-hepcidin\nIL-6 induced hepcidin in the tested human liver-cell, mouse and volunteer systems.\nCondition category: biomarker_context\nnutrient_topic: Iron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Inflammation can turn up the hormone that restricts iron release.\norganism: Humans and mice\ntissue_or_cell_type: Liver and circulation\nexperimental_model: Human liver-cell, mouse and human-volunteer inflammation experiments\nlimitations: IL-6 dependence applies to the tested inflammatory models, not every possible inflammatory iron pathway.\nexposure: IL-6 and inflammatory stimulation\nevidence_span: {\"source_cache\": \"artifacts/iron-research/15124018.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f2ed307ef57c255917685bb7bfb1f02f3a6481c732cc2ee41ad1f338e2a2a830\", \"start_char\": 0, \"end_char\": 578, \"text_sha256\": \"f2ed307ef57c255917685bb7bfb1f02f3a6481c732cc2ee41ad1f338e2a2a830\"}\n[iron-p15124018] IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. (2004). https://pubmed.ncbi.nlm.nih.gov/15124018/ DOI: 10.1172/jci20945","model_system":"Human liver-cell, mouse and human-volunteer inflammation experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iron-p15124018] IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. (2004). https://pubmed.ncbi.nlm.nih.gov/15124018/ DOI: 10.1172/jci20945","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1560864c-91d1-58dc-90c4-49bf61aba3de","stable_key":"import-e13b03e1-a614-543a-ac1b-97df18cfe30d","title":"Iron: absorption, trafficking, iron-dependent enzymes and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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