{"id":"ca51296e-5782-5ab5-bda5-4a0f20c148de","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-kat2-kyna","predicate":"supports_formation","statement":"Human KAT-II transaminates kynurenine to an intermediate that leads to kynurenic acid.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f21d4c69-696d-5a66-95e3-8e01f1980e13","mechanism_event_label":"Kynurenine can be diverted into a neuroactive branch.","subject":{"id":"b0d4ed40-858b-50e8-acbb-669452624d93","slug":"aadat","display_name":"AADAT / KAT II","entity_type_key":"protein"},"object":{"id":"6a123629-5a43-57ef-bba0-c429005ab5b3","slug":"kynurenic-acid","display_name":"Kynurenic acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"f21d4c69-696d-5a66-95e3-8e01f1980e13","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-kat2-kyna-event","event_type":"observed_relationship","label":"Kynurenine can be diverted into a neuroactive branch.","description":"Human KAT-II transaminates kynurenine to an intermediate that leads to kynurenic acid.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b0d4ed40-858b-50e8-acbb-669452624d93","slug":"aadat","display_name":"AADAT / KAT II","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6a123629-5a43-57ef-bba0-c429005ab5b3","slug":"kynurenic-acid","display_name":"Kynurenic acid","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ce72cbd6-7077-5f23-a859-a8000a3f8194","slug":"kynurenine","display_name":"L-Kynurenine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human enzyme structural study and catalytic characterization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The enzyme performs transamination; it does not directly perform every subsequent chemical rearrangement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Kynurenine can be diverted into a neuroactive branch.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27023527/ · DOI 10.3390/ijms17040446","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dc0c3e74-ccb6-5d98-8b15-631e34279531","evidence_kind":"source_excerpt","locator":"Lines 210-216","start_line":210,"end_line":216,"excerpt":"## tryptophan-kat2-kyna\nKynurenine can be diverted into a neuroactive branch.\nHuman KAT-II transaminates kynurenine to an intermediate that leads to kynurenic acid.\nModel: Human enzyme structural study and catalytic characterization.\nLimitations: The enzyme performs transamination; it does not directly perform every subsequent chemical rearrangement.\nEvidence access: Primary abstract\nStructure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27023527/ · DOI 10.3390/ijms17040446","model_system":"Human enzyme structural study and catalytic characterization.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73f9d3e7-fdc9-5418-8f3c-f4ef145f6efa","stable_key":"import-584c58f5-ab9f-53f3-97a9-55783db943b0","title":"Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7dfd20063b91900cb5c6ad675e3e675b7e25ef0fb8304eabac6f263cc5518284","revision_id":"bfafd789-fdf5-521f-bd28-c662e01ec1ea","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}