{"id":"ca44f9b3-d15e-51dc-b633-9ef628b90b96","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-beta-carotene-meal","predicate":"reduces","statement":"The beta-carotene plasma rise was smaller at 30 and 192 hours after the pectin meal; the 30-hour rise was reduced by more than half.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d17edb85-04bf-56c6-b71d-34f8d3b46449","mechanism_event_label":"The meal experiment found less beta-carotene appearing in blood.","subject":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"object":{"id":"0c7abce1-a93a-53e7-b279-e09023beacf8","slug":"postmeal-beta-carotene-response","display_name":"Human post-meal plasma beta-carotene response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d17edb85-04bf-56c6-b71d-34f8d3b46449","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-beta-carotene-meal-event","event_type":"observed_intervention","label":"The meal experiment found less beta-carotene appearing in blood.","description":"The beta-carotene plasma rise was smaller at 30 and 192 hours after the pectin meal; the 30-hour rise was reduced by more than half.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"73c24cd4-9ae8-5897-8359-fa4d9e8edecb","slug":"beta-carotene","display_name":"All-trans-beta-carotene","entity_type_key":"small_molecule"},"role":"affected_carotenoid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0c7abce1-a93a-53e7-b279-e09023beacf8","slug":"postmeal-beta-carotene-response","display_name":"Human post-meal plasma beta-carotene response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/1309477.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd0dad35ab4b3d100f22763fd9f5493d4ee5cc4e36f6f959436157484bd3f2f7\", \"start_char\": 0, \"end_char\": 1044, \"text_sha256\": \"fd0dad35ab4b3d100f22763fd9f5493d4ee5cc4e36f6f959436157484bd3f2f7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Crossover meal study in seven participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"12 g citrus pectin with 25 mg beta-carotene and a 500-kcal meal","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Plasma response is an absorption-related endpoint, not a direct vitamin A deficiency measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The meal experiment found less beta-carotene appearing in blood.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p1309477] Plasma beta-carotene response in humans after meals supplemented with dietary pectin. (1992). https://pubmed.ncbi.nlm.nih.gov/1309477/ DOI: 10.1093/ajcn/55.1.96","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Post-meal plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0e44a349-7c6e-564e-a8f9-27f1f870b67d","evidence_kind":"source_excerpt","locator":"Lines 659-670","start_line":659,"end_line":670,"excerpt":"### pectin-beta-carotene-meal\nThe beta-carotene plasma rise was smaller at 30 and 192 hours after the pectin meal; the 30-hour rise was reduced by more than half.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The meal experiment found less beta-carotene appearing in blood.\norganism: Homo sapiens\ntissue_or_cell_type: Post-meal plasma\nexperimental_model: Crossover meal study in seven participants\nlimitations: Plasma response is an absorption-related endpoint, not a direct vitamin A deficiency measurement.\nexposure: 12 g citrus pectin with 25 mg beta-carotene and a 500-kcal meal\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/1309477.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd0dad35ab4b3d100f22763fd9f5493d4ee5cc4e36f6f959436157484bd3f2f7\", \"start_char\": 0, \"end_char\": 1044, \"text_sha256\": \"fd0dad35ab4b3d100f22763fd9f5493d4ee5cc4e36f6f959436157484bd3f2f7\"}\n[pectin-p1309477] Plasma beta-carotene response in humans after meals supplemented with dietary pectin. 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