{"id":"ca2c33fe-5ebb-593e-9927-3137c515aaf0","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-fractional-retention","predicate":"lowers_fractional_storage_at_high_intake","statement":"Modeled fractional tissue storage was lower during repletion than during depletion, while urinary elimination increased.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a25d23f2-e846-53c9-a895-b58cca23a23e","mechanism_event_label":"Higher intake did not translate proportionally into more tissue storage.","subject":{"id":"36447b98-3392-559f-b76c-035726a2538e","slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"},"object":{"id":"d85260aa-b03c-53da-bd11-7410ecb6d15e","slug":"molybdenum-tissue-retention","display_name":"Fractional molybdenum tissue retention","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a25d23f2-e846-53c9-a895-b58cca23a23e","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-fractional-retention-event","event_type":"observed_intervention","label":"Higher intake did not translate proportionally into more tissue storage.","description":"Modeled fractional tissue storage was lower during repletion than during depletion, while urinary elimination increased.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36447b98-3392-559f-b76c-035726a2538e","slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d85260aa-b03c-53da-bd11-7410ecb6d15e","slug":"molybdenum-tissue-retention","display_name":"Fractional molybdenum tissue retention","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/16549456.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7c6337cd055a31e872ec0f2b24ea7419d5263cdcc6285cbc635e1ffe8f692468\", \"start_char\": 0, \"end_char\": 1679, \"text_sha256\": \"7c6337cd055a31e872ec0f2b24ea7419d5263cdcc6285cbc635e1ffe8f692468\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Compartmental reanalysis of four-man depletion/repletion tracer experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"102 days at 22 micrograms/day; 18 days at 467 micrograms/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Model estimates and adaptations, not an independent clinical trial or universal blood threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Higher intake did not translate proportionally into more tissue storage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p16549456] Molybdenum kinetics in men differ during molybdenum depletion and repletion. 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