{"id":"c9eb8573-b133-5453-be58-59c2df083afc","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-baboon-urinary-hydroxykynurenine","predicate":"supports","statement":"Riboflavin-deficient baboons excreted approximately one tenth as much urinary 3-hydroxykynurenine in the reported dietary comparison.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"57784730-f82e-578d-b846-40e17c481179","mechanism_event_label":"Dietary B2 deficiency changed a measured tryptophan-pathway product.","subject":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"object":{"id":"215d55a2-1657-589c-aaf4-afd1957859e7","slug":"3-hydroxykynurenine","display_name":"3-Hydroxy-L-kynurenine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"57784730-f82e-578d-b846-40e17c481179","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-baboon-urinary-hydroxykynurenine-event","event_type":"observed_intervention","label":"Dietary B2 deficiency changed a measured tryptophan-pathway product.","description":"Riboflavin-deficient baboons excreted approximately one tenth as much urinary 3-hydroxykynurenine in the reported dietary comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"215d55a2-1657-589c-aaf4-afd1957859e7","slug":"3-hydroxykynurenine","display_name":"3-Hydroxy-L-kynurenine","entity_type_key":"small_molecule"},"role":"urinary endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Dietary B2 status influences a tryptophan/niacin-pathway readout.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Dietary riboflavin-deficient, pyridoxine-deficient, pair-fed and natural-diet baboons; urinary and erythrocyte measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Experimental riboflavin-deficient diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Indexed abstract does not give diet duration or group size; urinary output is not a direct tissue KMO flux measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Riboflavin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Papio species (baboon)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Dietary B2 deficiency changed a measured tryptophan-pathway product.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[verjee1975] Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency. (1975). https://pubmed.ncbi.nlm.nih.gov/23659/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"288605d9-4e41-5de5-9234-2f18b9fa8757","evidence_kind":"source_excerpt","locator":"Lines 1276-1288","start_line":1276,"end_line":1288,"excerpt":"### b2-baboon-urinary-hydroxykynurenine\nRiboflavin-deficient baboons excreted approximately one tenth as much urinary 3-hydroxykynurenine in the reported dietary comparison.\nCondition category: nutrient_deficiency\nnutrient_topic: Riboflavin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Dietary B2 deficiency changed a measured tryptophan-pathway product.\norganism: Papio species (baboon)\ntissue_or_cell_type: Urine\nexperimental_model: Dietary riboflavin-deficient, pyridoxine-deficient, pair-fed and natural-diet baboons; urinary and erythrocyte measurements.\nlimitations: Indexed abstract does not give diet duration or group size; urinary output is not a direct tissue KMO flux measurement.\nexposure: Experimental riboflavin-deficient diet\ncross_nutrient: Dietary B2 status influences a tryptophan/niacin-pathway readout.\nevidence_location: Abstract\n[verjee1975] Tryptophan metabolism in baboons: effect of riboflavin and pyridoxine deficiency. 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